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Volume 20
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10.3390/ijms20174171
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Review

Syntenin: PDZ Protein Regulating Signaling Pathways and Cellular Functions

by
Tadayuki Shimada
*,
Shin Yasuda
,
Hiroko Sugiura
and
Kanato Yamagata
*
Synaptic Plasticity Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(17), 4171; https://doi.org/10.3390/ijms20174171
Submission received: 26 June 2019 / Revised: 22 August 2019 / Accepted: 22 August 2019 / Published: 26 August 2019
(This article belongs to the Section Molecular Biology)
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Abstract

Syntenin is an adaptor-like molecule that has two adjacent tandem postsynaptic density protein 95/Discs large protein/Zonula occludens 1 (PDZ) domains. The PDZ domains of syntenin recognize multiple peptide motifs with low to moderate affinity. Many reports have indicated interactions between syntenin and a plethora of proteins. Through interactions with various proteins, syntenin regulates the architecture of the cell membrane. As a result, increases in syntenin levels induce the metastasis of tumor cells, protrusion along the neurite in neuronal cells, and exosome biogenesis in various cell types. Here, we review the updated data that support various roles for syntenin in the regulation of neuronal synapses, tumor cell invasion, and exosome control.
Keywords: syntenin; membrane architecture; synapse; tumor metastasis; exosome biogenesis syntenin; membrane architecture; synapse; tumor metastasis; exosome biogenesis

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MDPI and ACS Style

Shimada, T.; Yasuda, S.; Sugiura, H.; Yamagata, K. Syntenin: PDZ Protein Regulating Signaling Pathways and Cellular Functions. Int. J. Mol. Sci. 2019, 20, 4171. https://doi.org/10.3390/ijms20174171

AMA Style

Shimada T, Yasuda S, Sugiura H, Yamagata K. Syntenin: PDZ Protein Regulating Signaling Pathways and Cellular Functions. International Journal of Molecular Sciences. 2019; 20(17):4171. https://doi.org/10.3390/ijms20174171

Chicago/Turabian Style

Shimada, Tadayuki, Shin Yasuda, Hiroko Sugiura, and Kanato Yamagata. 2019. "Syntenin: PDZ Protein Regulating Signaling Pathways and Cellular Functions" International Journal of Molecular Sciences 20, no. 17: 4171. https://doi.org/10.3390/ijms20174171

APA Style

Shimada, T., Yasuda, S., Sugiura, H., & Yamagata, K. (2019). Syntenin: PDZ Protein Regulating Signaling Pathways and Cellular Functions. International Journal of Molecular Sciences, 20(17), 4171. https://doi.org/10.3390/ijms20174171

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