Next Article in Journal
Deficiency of Mitochondrial Aspartate-Glutamate Carrier 1 Leads to Oligodendrocyte Precursor Cell Proliferation Defects Both In Vitro and In Vivo
Next Article in Special Issue
Beneficial and Deleterious Effects of Female Sex Hormones, Oral Contraceptives, and Phytoestrogens by Immunomodulation on the Liver
Previous Article in Journal
Long-Term Vemurafenib Exposure Induced Alterations of Cell Phenotypes in Melanoma: Increased Cell Migration and Its Association with EGFR Expression
Previous Article in Special Issue
European Patent in Immunoncology: From Immunological Principles of Implantation to Cancer Treatment
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 20
Issue 18
10.3390/ijms20184485
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Fucoxanthin-Rich Brown Algae Extract Improves Male Reproductive Function on Streptozotocin-Nicotinamide-Induced Diabetic Rat Model

by
Zwe-Ling Kong
1,2,*,
Sabri Sudirman
1,
Yu-Chun Hsu
1,
Chieh-Yu Su
1 and
Hsiang-Ping Kuo
2
1
Department of Food Science, National Taiwan Ocean University, Keelung 20224, Taiwan
2
Biotaiwan Foundation, New Taipei City 24886, Taiwan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(18), 4485; https://doi.org/10.3390/ijms20184485
Submission received: 26 August 2019 / Revised: 9 September 2019 / Accepted: 10 September 2019 / Published: 11 September 2019
(This article belongs to the Special Issue Reproductive Immunology: Cellular and Molecular Biology)
Browse Figures
Review Reports Versions Notes

Abstract

Hypogonadism and oxidative stress are occurring commonly in men with diabetes and associated male infertility. This study aimed to investigate the capability of anti-oxidative and anti-inflammatory properties of fucoxanthin as well as to evaluate its protective effects on male reproduction in diabetic rats. The RAW 264.7 macrophage cells were used to evaluate the anti-oxidative and anti-inflammatory activity. Thirty male Sprague-Dawley rats were induced by streptozotocin-nicotinamide for a diabetes model and fed either with three different doses of fucoxanthin (13, 26, and 65 mg/kg) or rosiglitazone (0.571 mg/kg) for four weeks. The fucoxanthin significantly inhibited nitric oxide production and reduced reactive oxygen species level in lipopolysaccharide-induced RAW 264.7 cells. In the animal study, fucoxanthin administration improved insulin resistance, restored sperm motility, decreased abnormal sperm number, and inhibited lipid peroxidation. Moreover, it restored GPR54 and SOCS-3 mRNA expression in the hypothalamus and recovered luteinizing hormone level, as well as the testosterone level. In conclusion, fucoxanthin not only possessed antioxidant and anti-inflammatory properties but also decreased the diabetes signs and symptoms as well as improved spermatogenesis and male reproductive function.
Keywords: diabetes; fucoxanthin; hypogonadism; male reproduction; spermatogenesis diabetes; fucoxanthin; hypogonadism; male reproduction; spermatogenesis
Graphical Abstract

Share and Cite

MDPI and ACS Style

Kong, Z.-L.; Sudirman, S.; Hsu, Y.-C.; Su, C.-Y.; Kuo, H.-P. Fucoxanthin-Rich Brown Algae Extract Improves Male Reproductive Function on Streptozotocin-Nicotinamide-Induced Diabetic Rat Model. Int. J. Mol. Sci. 2019, 20, 4485. https://doi.org/10.3390/ijms20184485

AMA Style

Kong Z-L, Sudirman S, Hsu Y-C, Su C-Y, Kuo H-P. Fucoxanthin-Rich Brown Algae Extract Improves Male Reproductive Function on Streptozotocin-Nicotinamide-Induced Diabetic Rat Model. International Journal of Molecular Sciences. 2019; 20(18):4485. https://doi.org/10.3390/ijms20184485

Chicago/Turabian Style

Kong, Zwe-Ling, Sabri Sudirman, Yu-Chun Hsu, Chieh-Yu Su, and Hsiang-Ping Kuo. 2019. "Fucoxanthin-Rich Brown Algae Extract Improves Male Reproductive Function on Streptozotocin-Nicotinamide-Induced Diabetic Rat Model" International Journal of Molecular Sciences 20, no. 18: 4485. https://doi.org/10.3390/ijms20184485

APA Style

Kong, Z.-L., Sudirman, S., Hsu, Y.-C., Su, C.-Y., & Kuo, H.-P. (2019). Fucoxanthin-Rich Brown Algae Extract Improves Male Reproductive Function on Streptozotocin-Nicotinamide-Induced Diabetic Rat Model. International Journal of Molecular Sciences, 20(18), 4485. https://doi.org/10.3390/ijms20184485

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop