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Volume 21
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10.3390/ijms21165603
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Article

A Plant-Derived Antigen–Antibody Complex Induces Anti-Cancer Immune Responses by Forming a Large Quaternary Structure

by
Deuk-Su Kim
1,
Yang Joo Kang
1,
Kyung Jin Lee
1,
Lu Qiao
1,
Kinarm Ko
2,
Dae Heon Kim
3,
Soon Chul Myeung
4 and
Kisung Ko
1,*
1
Department of Medicine, Therapeutic Protein Engineering Lab, College of Medicine, Chung-Ang University, Seoul 06974, Korea
2
Department of Stem Cell Biology, School of Medicine, Konkuk University, Seoul 06974, Korea
3
Department of Biology, Sunchon National University, Sunchon 57922, Korea
4
Department of Urology, Chung-Ang University, College of Medicine, Seoul 06974, Korea
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(16), 5603; https://doi.org/10.3390/ijms21165603
Submission received: 1 July 2020 / Revised: 30 July 2020 / Accepted: 2 August 2020 / Published: 5 August 2020
(This article belongs to the Section Molecular Plant Sciences)
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Abstract

The antigen–antibody complex (AAC) has novel functions for immunomodulation, encouraging the application of diverse quaternary protein structures for vaccination. In this study, GA733 antigen and anti-GA733 antibody proteins were both co-expressed to obtain the AAC protein structures in a F1 plant obtained by crossing the plants expressing each protein. In F1 plant, the antigen and antibody assembled to form a large quaternary circular ACC structure (~30 nm). The large quaternary protein structures induced immune response to produce anticancer immunoglobulins G (IgGs) that are specific to the corresponding antigens in mouse. The serum containing the anticancer IgGs inhibited the human colorectal cancer cell growth in the xenograft nude mouse. Taken together, antigens and antibodies can be assembled to form AAC protein structures in plants. Plant crossing represents an alternative strategy for the formation of AAC vaccines that efficiently increases anticancer antibody production.
Keywords: antigen-antibody complex; colorectal cancer; large quaternary structure; plant crossing; vaccine antigen-antibody complex; colorectal cancer; large quaternary structure; plant crossing; vaccine
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MDPI and ACS Style

Kim, D.-S.; Kang, Y.J.; Lee, K.J.; Qiao, L.; Ko, K.; Kim, D.H.; Myeung, S.C.; Ko, K. A Plant-Derived Antigen–Antibody Complex Induces Anti-Cancer Immune Responses by Forming a Large Quaternary Structure. Int. J. Mol. Sci. 2020, 21, 5603. https://doi.org/10.3390/ijms21165603

AMA Style

Kim D-S, Kang YJ, Lee KJ, Qiao L, Ko K, Kim DH, Myeung SC, Ko K. A Plant-Derived Antigen–Antibody Complex Induces Anti-Cancer Immune Responses by Forming a Large Quaternary Structure. International Journal of Molecular Sciences. 2020; 21(16):5603. https://doi.org/10.3390/ijms21165603

Chicago/Turabian Style

Kim, Deuk-Su, Yang Joo Kang, Kyung Jin Lee, Lu Qiao, Kinarm Ko, Dae Heon Kim, Soon Chul Myeung, and Kisung Ko. 2020. "A Plant-Derived Antigen–Antibody Complex Induces Anti-Cancer Immune Responses by Forming a Large Quaternary Structure" International Journal of Molecular Sciences 21, no. 16: 5603. https://doi.org/10.3390/ijms21165603

APA Style

Kim, D.-S., Kang, Y. J., Lee, K. J., Qiao, L., Ko, K., Kim, D. H., Myeung, S. C., & Ko, K. (2020). A Plant-Derived Antigen–Antibody Complex Induces Anti-Cancer Immune Responses by Forming a Large Quaternary Structure. International Journal of Molecular Sciences, 21(16), 5603. https://doi.org/10.3390/ijms21165603

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