Cancer Cell Metabolism in Hypoxia: Role of HIF-1 as Key Regulator and Therapeutic Target

Infantino, Vittoria; Santarsiero, Anna; Convertini, Paolo; Todisco, Simona; Iacobazzi, Vito

doi:10.3390/ijms22115703

Open AccessReview

Cancer Cell Metabolism in Hypoxia: Role of HIF-1 as Key Regulator and Therapeutic Target

by

Vittoria Infantino

¹

,

Anna Santarsiero

¹

,

Paolo Convertini

¹

,

Simona Todisco

^1,* and

Vito Iacobazzi

^2,*

¹

Department of Science, University of Basilicata, Viale dell’Ateneo Lucano 10, 85100 Potenza, Italy

²

Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Via Orabona 4, 70125 Bari, Italy

^*

Authors to whom correspondence should be addressed.

Int. J. Mol. Sci. 2021, 22(11), 5703; https://doi.org/10.3390/ijms22115703

Submission received: 27 April 2021 / Revised: 18 May 2021 / Accepted: 24 May 2021 / Published: 27 May 2021

(This article belongs to the Special Issue Cancer Cell Metabolism)

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Abstract

In order to meet the high energy demand, a metabolic reprogramming occurs in cancer cells. Its role is crucial in promoting tumor survival. Among the substrates in demand, oxygen is fundamental for bioenergetics. Nevertheless, tumor microenvironment is frequently characterized by low-oxygen conditions. Hypoxia-inducible factor 1 (HIF-1) is a pivotal modulator of the metabolic reprogramming which takes place in hypoxic cancer cells. In the hub of cellular bioenergetics, mitochondria are key players in regulating cellular energy. Therefore, a close crosstalk between mitochondria and HIF-1 underlies the metabolic and functional changes of cancer cells. Noteworthy, HIF-1 represents a promising target for novel cancer therapeutics. In this review, we summarize the molecular mechanisms underlying the interplay between HIF-1 and energetic metabolism, with a focus on mitochondria, of hypoxic cancer cells.

Keywords: HIF-1; cancer metabolism; hypoxia; TCA cycle; mitochondria

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Infantino, V.; Santarsiero, A.; Convertini, P.; Todisco, S.; Iacobazzi, V. Cancer Cell Metabolism in Hypoxia: Role of HIF-1 as Key Regulator and Therapeutic Target. Int. J. Mol. Sci. 2021, 22, 5703. https://doi.org/10.3390/ijms22115703

AMA Style

Infantino V, Santarsiero A, Convertini P, Todisco S, Iacobazzi V. Cancer Cell Metabolism in Hypoxia: Role of HIF-1 as Key Regulator and Therapeutic Target. International Journal of Molecular Sciences. 2021; 22(11):5703. https://doi.org/10.3390/ijms22115703

Chicago/Turabian Style

Infantino, Vittoria, Anna Santarsiero, Paolo Convertini, Simona Todisco, and Vito Iacobazzi. 2021. "Cancer Cell Metabolism in Hypoxia: Role of HIF-1 as Key Regulator and Therapeutic Target" International Journal of Molecular Sciences 22, no. 11: 5703. https://doi.org/10.3390/ijms22115703

APA Style

Infantino, V., Santarsiero, A., Convertini, P., Todisco, S., & Iacobazzi, V. (2021). Cancer Cell Metabolism in Hypoxia: Role of HIF-1 as Key Regulator and Therapeutic Target. International Journal of Molecular Sciences, 22(11), 5703. https://doi.org/10.3390/ijms22115703

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Cancer Cell Metabolism in Hypoxia: Role of HIF-1 as Key Regulator and Therapeutic Target

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