Hijacked Immune Cells in the Tumor Microenvironment: Molecular Mechanisms of Immunosuppression and Cues to Improve T Cell-Based Immunotherapy of Solid Tumors
Round 1
Reviewer 1 Report
The authors proposed to review the molecular mechanisms of immunosuppression and cues to improve T cell based IMT in solid tumors. The review is thorough and timely for the field. I have few suggestions to improve it.
- It will be greatly helpful, if the authors can include a section to discuss the emerging biomarkers (from clinical trials or retrospective analysis) to predict the IMT response, and their link with biological mechanisms studies.
- Besides the TME, the host immune environment and other factors can affect the TME and IMT response, can authors also provide some review on this part?
- Besides the biological mechanisms study, imaging (radiomics, deep learning) and radiogenomics studies have been proposed to predict the response to IMR (my group has published a recent paper https://doi.org/10.1016/j.semcancer.2020.12.005), the authors may want to discuss this point.
Author Response
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Author Response File: 
Author Response.pdf
Reviewer 2 Report
Samstag et al contributed a well-organized, well-written review paper focusing TME in solid tumors. The authors discussed a wide range of components in TME that shaped immune evasion, including immune cells and other factors. They proposed a variety of corresponding strategies to tackle the immunosuppression in TME. The manuscript is acceptable for publication in this journal in the present form.
Author Response
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Author Response File: Author Response.pdf
