Pulmonary Stretch and Lung Mechanotransduction: Implications for Progression in the Fibrotic Lung
Abstract
:1. Background
2. Matrix Abnormalities and Mechanical Behavior in Pulmonary Fibrosis
3. Stress and Strain Behavior of the Normal and Pathologic Lung
4. The Micro-Strain Concept in the Fibrotic Lung
5. The Mechanotransduction Process: Biological Response to Stretch and Progression in the Fibrotic Lung
6. Role of Alveolar Type 2 Cells in the Progression of Lung Fibrosis
7. Conclusions and Clinical Implications
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Acknowledgments
Conflicts of Interest
References
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Marchioni, A.; Tonelli, R.; Cerri, S.; Castaniere, I.; Andrisani, D.; Gozzi, F.; Bruzzi, G.; Manicardi, L.; Moretti, A.; Demurtas, J.; et al. Pulmonary Stretch and Lung Mechanotransduction: Implications for Progression in the Fibrotic Lung. Int. J. Mol. Sci. 2021, 22, 6443. https://doi.org/10.3390/ijms22126443
Marchioni A, Tonelli R, Cerri S, Castaniere I, Andrisani D, Gozzi F, Bruzzi G, Manicardi L, Moretti A, Demurtas J, et al. Pulmonary Stretch and Lung Mechanotransduction: Implications for Progression in the Fibrotic Lung. International Journal of Molecular Sciences. 2021; 22(12):6443. https://doi.org/10.3390/ijms22126443
Chicago/Turabian StyleMarchioni, Alessandro, Roberto Tonelli, Stefania Cerri, Ivana Castaniere, Dario Andrisani, Filippo Gozzi, Giulia Bruzzi, Linda Manicardi, Antonio Moretti, Jacopo Demurtas, and et al. 2021. "Pulmonary Stretch and Lung Mechanotransduction: Implications for Progression in the Fibrotic Lung" International Journal of Molecular Sciences 22, no. 12: 6443. https://doi.org/10.3390/ijms22126443