The Macrophage Iron Signature in Health and Disease
Abstract
:1. Iron and Macrophage Polarization—A General View
2. MΦ in Systemic Iron Homeostasis
3. Gastrointestinal System
3.1. Gut MΦ
3.2. Other MΦ Populations in the Gastrointestinal System
3.3. MΦ and Malignancies of the Gastrointestinal System
4. Cardiovascular System
4.1. Cardiac MΦ Populations
4.2. Role of Iron and MΦ in Cardiac Inflammation and Disease
5. Kidney
5.1. MΦ Phenotypes in Acute and Chronic Renal Pathologies
5.2. Renal Iron Handling—MΦ versus Tubular Epithelial Cells
6. Lung
6.1. MΦ Populations in the Lung
6.2. Iron and Lung MΦ
7. Brain and Nerves
7.1. The MΦ–Iron Liason in the Central Nervous System (CNS)
7.2. MΦ Populations in the Peripheral Nervous System (Ganglia and Nerves)
8. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Mertens, C.; Marques, O.; Horvat, N.K.; Simonetti, M.; Muckenthaler, M.U.; Jung, M. The Macrophage Iron Signature in Health and Disease. Int. J. Mol. Sci. 2021, 22, 8457. https://doi.org/10.3390/ijms22168457
Mertens C, Marques O, Horvat NK, Simonetti M, Muckenthaler MU, Jung M. The Macrophage Iron Signature in Health and Disease. International Journal of Molecular Sciences. 2021; 22(16):8457. https://doi.org/10.3390/ijms22168457
Chicago/Turabian StyleMertens, Christina, Oriana Marques, Natalie K. Horvat, Manuela Simonetti, Martina U. Muckenthaler, and Michaela Jung. 2021. "The Macrophage Iron Signature in Health and Disease" International Journal of Molecular Sciences 22, no. 16: 8457. https://doi.org/10.3390/ijms22168457