The Role of Antimicrobial Peptides in Preterm Birth
Abstract
:1. Introduction
2. AMPs in PTB
2.1. Properties and Classification of AMPs
2.2. Mechanism of Action of AMPs
2.2.1. Antimicrobial Actions
2.2.2. Immunoregulatory Functions of AMPs
2.2.3. AMP-Microbiome Interaction
3. Expression of AMPs in Pregnancy
4. AMPs Associated with PTB
5. Conclusions and Future Perspectives
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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AMPs | Gene | Site of Expression | Gestational Weeks of Sample Collection | Expression Associated with PTB | References |
---|---|---|---|---|---|
HNP 1-3 | DEFA1,3 | Vagina | 24–29 | PTB <32 weeks ↑ | [117] |
PTB <37 weeks ↔ | |||||
Mid-pregnancy | PTB ↑ in African American | [119] | |||
PTB ↔ in non-Hispanic Whites | |||||
Amniotic fluid | 19–33 | Intra-amniotic infection ↑ | [41] | ||
PPROM ↑ | |||||
Preterm parturition ↑ | |||||
24–34 | Subclinical intrauterine infection ↑ | [98] | |||
Fetal membranes | 23–33 | Histologic chorioamnionitis ↑ | [126] | ||
PPROM ↑ | |||||
Beta-defensins | |||||
HBD-1 | DEFB1 | Amniotic fluid | 20–32 | IAI ↑ | [106] |
HBD-2 | DEFB2 | Vagina | 16–28 | PTB < 37 weeks ↓ | [39] |
Amniotic fluid | 20–32 | Intra-amniotic infection ↑ | [105] | ||
IAI ↑ | |||||
Preterm delivery ↑ | |||||
HBD-3 | DEFB3 | Amniotic fluid | 20–32 | Intra-amniotic infection ↑ | [40] |
Cathelicidin | CAMP | Vagina | 10–24 | Cervical shortening ↑ | [120] |
PTB < 37 weeks ↑ | |||||
Amniotic fluid | 24–34 | PPROM with Intra-amniotic infection ↑ | [122] |
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Son, G.-H.; Lee, J.-J.; Kim, Y.; Lee, K.-Y. The Role of Antimicrobial Peptides in Preterm Birth. Int. J. Mol. Sci. 2021, 22, 8905. https://doi.org/10.3390/ijms22168905
Son G-H, Lee J-J, Kim Y, Lee K-Y. The Role of Antimicrobial Peptides in Preterm Birth. International Journal of Molecular Sciences. 2021; 22(16):8905. https://doi.org/10.3390/ijms22168905
Chicago/Turabian StyleSon, Ga-Hyun, Jae-Jun Lee, Youngmi Kim, and Keun-Young Lee. 2021. "The Role of Antimicrobial Peptides in Preterm Birth" International Journal of Molecular Sciences 22, no. 16: 8905. https://doi.org/10.3390/ijms22168905