The New Molecular Mechanism of Preterm Birth
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 7728
Special Issue Editor
Special Issue Information
Dear Colleagues,
Preterm birth (PTB) remains the biggest challenge in obstetrics, and a better understating of underlying cellular and molecular mechanisms is needed. Genetic alterations, environmental toxicants, or an internal infection may cause uterine distention, maternal-fetal oxidative stress, or cervical dysfunction, which trigger parturition to spontaneous preterm labor (PTL) or preterm premature rupture of membrane (PPROM). Advancement in molecular techniques such as metagenomics, microbiomics, and metabolomics opens a new horizon to elucidate the precise cellular and molecular signaling pathway of PTB. Microbiota dysbiosis might directly affect the production of microbiota-generated metabolites and lead to metabolic dysfunction in immune response and maternal-uterine or fetal cellular membranes (amnion and chorion), which stimulate the inflammatory cytokines (IL-6, TNF-a) signaling pathway and induce PTB. The detection of omics markers in maternal bio-fluid (plasma, cervicovaginal, and amniotic fluid) at different trimesters, in a well-defined population, could reveal the accurate cellular and molecular mechanisms, predictive biomarkers, and biotics/therapeutics development for PTB.
Dr. Young Ju Kim
Guest Editor
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Keywords
- Preterm
- Microbiota
- Metabolites
- Metabolomics
- Metagenomics
- Microbiomics
- Biomarkers
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