Tumor-Progressive Mechanisms Mediating miRNA–Protein Interaction
Abstract
:1. Introduction
2. miRNA-Mediated Protein Regulation in Cancer Cells
2.1. RNA-Binding Proteins
2.2. RBPs in Cancer Progression and Suppression
2.3. miRNA–RBP Binding Functions in Cancer Cells
2.4. Strategies for Identifying Interactions between miRNAs and RBPs
3. Future Perspectives
Author Contributions
Funding
Conflicts of Interest
References
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miRNA | Type of Pathway | Target | Type of Cancer | Function | Reference |
---|---|---|---|---|---|
miR-328 | Decoy | hnRNP E2-CEBPα mRNA | Leukemic blasts | Differentiation | Eiring AM, Cell 2010 |
Canonical | PIM1 mRNA | Decreased survival | |||
miR-29 | Decoy | HuR-A20 mRNA | Sarcoma | Differentiation | Balkhi MY, Sci signal, 2013 |
miR-26a, -584 | Decoy | hnRNP A1-CDK6 mRNA | Colorectal cancer | Cell growth suppression | Konishi H, Biochem Biophys Res Commun. 2015 |
miR-574-3p | Decoy | hnRNP L-VEGFA mRNA | Myeloid cells | Inhibition of cell proliferation | Yao P, Nucleic Acids Research, 2017 |
Canonical | EP300 mRNA | ||||
miR-574-5p | Decoy | CUGBP1-mPGES-1 mRNA | Lung tumor | Cell growth promotion | Saul MJ, FASEB J, 2019 |
miR-18a | Degradation | hnRNP A1 | Colorectal cancer | Apoptosis induction | Fujiya M, Oncogene, 2014 |
miRs with Greater than 4-Fold Expression Compared to the Isotype Control IgG | |||
---|---|---|---|
Name | ID | Ratio (hnRNP A1/IgG) | LOG2ratio |
hsa-miR-29a-3p | MIMAT0000086 | 11.49 | 3.52 |
hsa-miR-26a-5p | MIMAT0000082 | 11.37 | 3.51 |
hsa-miR-584-5p | MIMAT0003249 | 9.93 | 3.31 |
hsa-miR-107 | MIMAT0000104 | 9.73 | 3.28 |
hsa-miR-106b-5p | MIMAT0000680 | 8.99 | 3.17 |
hsa-miR-1229-5p | MIMAT0022942 | 8.88 | 3.15 |
hsa-miR-29b-3p | MIMAT0000100 | 8.07 | 3.01 |
hsa-miR-194-5p | MIMAT0000460 | 8.07 | 3.01 |
hsa-miR-142-3p | MIMAT0000434 | 7.97 | 2.99 |
hsa-miR-18a-5p | MIMAT0000072 | 7.93 | 2.99 |
hsa-let-7c-5p | MIMAT0000064 | 7.31 | 2.87 |
hsa-miR-16-5p | MIMAT0000069 | 7.22 | 2.85 |
hsa-miR-500a-3p | MIMAT0002871 | 6.96 | 2.8 |
hsa-miR-200b-3p | MIMAT0000318 | 6.89 | 2.78 |
hsa-miR-19a-3p | MIMAT0000073 | 6.55 | 2.71 |
hsa-miR-222-3p | MIMAT0000279 | 6.4 | 2.68 |
hsa-let-7b-5p | MIMAT0000063 | 5.98 | 2.58 |
hsa-miR-23a-3p | MIMAT0000078 | 5.97 | 2.58 |
hsa-let-7d-5p | MIMAT0000065 | 5.85 | 2.55 |
hsa-miR-431-3p | MIMAT0004757 | 5.7 | 2.51 |
hsa-miR-200c-3p | MIMAT0000617 | 5.62 | 2.49 |
hsa-miR-23b-3p | MIMAT0000418 | 5.27 | 2.4 |
hsa-miR-27b-3p | MIMAT0000419 | 5.23 | 2.39 |
hsa-miR-19b-3p | MIMAT0000074 | 5.05 | 2.34 |
hsa-miR-103a-3p | MIMAT0000101 | 4.95 | 2.31 |
hsa-miR-1246 | MIMAT0005898 | 4.73 | 2.24 |
hsa-let-7a-5p | MIMAT0000062 | 4.66 | 2.22 |
hsa-miR-20a-5p | MIMAT0000075 | 4.5 | 2.17 |
hsa-miR-27a-3p | MIMAT0000084 | 4.49 | 2.17 |
hsa-miR-141-3p | MIMAT0000432 | 4.32 | 2.11 |
hsa-miR-21-5p | MIMAT0000076 | 4.25 | 2.09 |
hsa-miR-17-5p | MIMAT0000070 | 4.24 | 2.08 |
hsa-miR-106a-5p | MIMAT0000103 | 4.15 | 2.05 |
hsa-miR-20b-5p | MIMAT0001413 | 4.11 | 2.04 |
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Konishi, H.; Sato, H.; Takahashi, K.; Fujiya, M. Tumor-Progressive Mechanisms Mediating miRNA–Protein Interaction. Int. J. Mol. Sci. 2021, 22, 12303. https://doi.org/10.3390/ijms222212303
Konishi H, Sato H, Takahashi K, Fujiya M. Tumor-Progressive Mechanisms Mediating miRNA–Protein Interaction. International Journal of Molecular Sciences. 2021; 22(22):12303. https://doi.org/10.3390/ijms222212303
Chicago/Turabian StyleKonishi, Hiroaki, Hiroki Sato, Kenji Takahashi, and Mikihiro Fujiya. 2021. "Tumor-Progressive Mechanisms Mediating miRNA–Protein Interaction" International Journal of Molecular Sciences 22, no. 22: 12303. https://doi.org/10.3390/ijms222212303