Cumulus Extracellular Matrix Is an Important Part of Oocyte Microenvironment in Ovarian Follicles: Its Remodeling and Proteolytic Degradation
Abstract
:1. Introduction
2. Hormone-Dependent Oocyte Microenvironment
3. Transesterification Process between Hyaluronan and the Inter-Alpha-Trypsin Inhibitor
4. Remodeling and Proteolytic Degradation of the ECM
5. Proteolytic Cleavage of the ECM Component Versican
6. Steroidogenesis and the Activity of Proteolytic Enzymes
7. Discussion
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
ECM | Extracellular matrix |
HA | Hyaluronan |
OCC | Oocyte–cumulus complex |
CCs | Cumulus cells |
FSH | Follicle-stimulating hormone |
LH | Luteinizing hormone |
LHR | Luteinizing hormone receptor |
V1 | Versican 1 |
VG1 | G1-domain from Versican 1 |
ADAMTS | A disintegrin and metalloprotease with thrombospondin type I motifs |
PVP | Polyvinylpyrolidone |
IαI | Inter-alpha-trypsin inhibitor |
HCs | Heavy chains from inter-alpha-trypsin inhibitors |
HAS2 | Hyaluronan synthase 2 |
TNFAIP6 | Tumor necrosis factor alpha-induced protein 6 |
PTX3 | Pentraxin 3 |
PA | Plasminogen activator |
MMPs | Metalloproteinases |
UPS | Ubiquitin–proteasome system |
PG | Proteoglycans |
TZPs | Transzonal projections |
GV | Germinal vesicle |
MAPK | Mitogen-activated protein kinase |
Mmp15 | Matrix metalloproteinase 15 |
GAG | Glycosaminoglycan |
Pgr | Progesterone receptor |
PRKO | Progesterone receptor knockout |
StAR | Steroidogenic acute regulatory protein |
PR | Progesterone receptor |
CDK | Cyclin-dependent protein kinase |
hRPF1 | Functional human homolog of RSP5 [93] |
E6-AP | E6-associated protein |
UBCH7 | Ubiquitin-conjugating enzyme |
SRC-1 | Steroid receptor coactivator-1 |
CSPGs | Chondroitin sulfate proteoglycans |
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Nagyová, E.; Němcová, L.; Camaioni, A. Cumulus Extracellular Matrix Is an Important Part of Oocyte Microenvironment in Ovarian Follicles: Its Remodeling and Proteolytic Degradation. Int. J. Mol. Sci. 2022, 23, 54. https://doi.org/10.3390/ijms23010054
Nagyová E, Němcová L, Camaioni A. Cumulus Extracellular Matrix Is an Important Part of Oocyte Microenvironment in Ovarian Follicles: Its Remodeling and Proteolytic Degradation. International Journal of Molecular Sciences. 2022; 23(1):54. https://doi.org/10.3390/ijms23010054
Chicago/Turabian StyleNagyová, Eva, Lucie Němcová, and Antonella Camaioni. 2022. "Cumulus Extracellular Matrix Is an Important Part of Oocyte Microenvironment in Ovarian Follicles: Its Remodeling and Proteolytic Degradation" International Journal of Molecular Sciences 23, no. 1: 54. https://doi.org/10.3390/ijms23010054