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Volume 23
Issue 12
10.3390/ijms23126682
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Review
Peer-Review Record

Immunological Pathomechanisms of Spongiotic Dermatitis in Skin Lesions of Atopic Dermatitis

Int. J. Mol. Sci. 2022, 23(12), 6682; https://doi.org/10.3390/ijms23126682
by Ryoji Tanei 1,* and Yasuko Hasegawa 2
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2022, 23(12), 6682; https://doi.org/10.3390/ijms23126682
Submission received: 14 May 2022 / Revised: 10 June 2022 / Accepted: 13 June 2022 / Published: 15 June 2022
(This article belongs to the Special Issue Molecular Advances in Skin Diseases)

Round 1

Reviewer 1 Report

ijms-1748994

 

Immunological pathomechanisms of spongiotic dermatitis in skin lesions of atopic dermatitis

 

This is a Review paper oriented to summarize the most relevant aspect of the complex related to atopic dermatitis.

Despite the essential lines conducted in this Review, some aspects should be considered:

 

1. In the Introduction section (lines 45 and 46) it is very much difficult to understand:

“…therefore, AD is considered an allergic disease that can become a lifelong condition.”

We have to recognize that we need still more evidence to confirm that atopic dermatitis can be considered as an allergic disease. Even more, some authors propose that atopic dermatitis is a previous step to allergic disease (food allergy, environmental…).

 

2. To propose that the pathogenic mechanism of spongiotic dermatitis is based on atopic dermatitis still constitutes a weak hypothesis.

 

3. It is difficult to establish a close relationship between spongiotic dermatitis “in adult” with atopic dermatitis, due to the multiple factors involved in the appearance of atopic eczema. Perhaps the “atopic eczema in the elderly” could be more extensively trated.

Comments for author File: Comments.pdf

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

This  review has included a comprehesive overview for the pathomechanism of spongiotic dermatitis. It is very good organization except some format issues and the figures. Some of the English is akward. 

The figures should insert to the manuscript as the other published papers in this journal. The author should re-arrange the figures in figure 2. Maybe a table could help somehow. 

The reference format in the texts should be consitent, such as [6, 7] and [6-7]. 

Staphylococcus aureus should be Italic. The author have to read through the manuscript to revise other similar issues. 

(121) should be [121].

 

 

 

 

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Round 2

Reviewer 1 Report

The authors have followed the most indications suggested.

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