Leukotriene A4 Hydrolase and Hepatocyte Growth Factor Are Risk Factors of Sudden Cardiac Death Due to First-Ever Myocardial Infarction
, Simon Vikström 2,†, Patrik Wennberg 3, Jan-Håkan Jansson 2, Jonas Andersson 2 and Elin Chorell 1Round 1
Reviewer 1 Report
The study is devoted to a very actual problem. At present, the clinical guidelines define a strategy for risk stratification of sudden cardiac death, and develop criteria for its assessment, both for the general population and for certain categories of patients, including patients who have had myocardial infarction. However, despite this, the problem persists. During the first year after myocardial infarction, the monitoring of these patients is more thorough, but after a few years it is not possible to determine clear specific criteria for the risk of sudden death for these patients. The tactics of managing such patients is equated with tactics for other chronic forms of coronary artery disease.
But as this study showed, at the time of myocardial infarction in each patient, the predominance of individual pro-inflammatory and prothrombotic factors is possible. And it is extremely important that the results of the study show, which of these factors may subsequently affect the risk of sudden death. The results of the study are convincing, because a careful selection of the patients themselves with registered sudden death was carried out, a control group with similar parameters was selected, and a thorough statistical analysis was carried out. Many markers have been studied, and the discussion section provides a literature review and possible mechanisms, that determine the association of these markers with the risk of sudden death.The study is of great clinical importance for the most accurate stratification of the risk of sudden death and the development of new methods for correcting this risk.
Reviewer 2 Report
In the current study Landfors et al. analyzed the predictive value of blood proteins with SCD due to first MI. As has been shown LTA4H and HGF were independently, after adjustment, associated with its occurrence. In accordance with authors and my best knowledge, there has not been published similar analysis in literature. As is well known, SCD is an extremely difficult research topic, mainly due to its unpredictability and often the inability to obtain the samples. The main advantage of the current study is the interesting study scheme, based on two large registries, which made it possible to conduct this type of analysis. Therefore, I recommend the publication of this article in IJMS.
