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Molecular Research of Hematological Changes in Cardiovascular Diseases
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Molecular Research of Hematological Changes in Cardiovascular Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (15 February 2023) | Viewed by 2780

Special Issue Editor

Dr. Svetlana Zavalishina

E-Mail Website
Guest Editor
Department of Adaptive Physical Culture and Recreation, Russian State Social University, Moscow, Russia
Interests: blood platelets; erythrocyte aggregation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The state of various hematological parameters is very important for maintaining health and the appearance of the disease. They react early and very sensitively to various external influences and any deviations from the functional optimum in the internal organs. Changes may relate to blood cells, biochemical, rheological, and immunological parameters.

Recently, hematological parameters have increasingly come to the attention of various researchers due to their early response to the appearance of various cardiovascular disorders. A large number of different changes in the blood during the formation of atherosclerosis, coronary heart disease, arterial hypertension, and heart failure have been revealed. The dynamics of hematological parameters can be considered as a marker of the progression of pathology and the success of therapy in cardiovascular diseases.

The collected information on hematological parameters indicates the need for additional research aimed at revealing the subtle mechanisms of the pathogenesis of cardiovascular diseases and elucidating the conditions for inhibiting the progression of pathology and reducing the risk of thrombotic complications.

Dr. Svetlana Yurievna Zavalishina
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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19 pages, 3746 KiB  
Article
Steady Laminar Flow Decreases Endothelial Glycolytic Flux While Enhancing Proteoglycan Synthesis and Antioxidant Pathways
by Sarah E. Basehore, Jonathan Garcia and Alisa Morss Clyne
Int. J. Mol. Sci. 2024, 25(5), 2485; https://doi.org/10.3390/ijms25052485 - 20 Feb 2024
Viewed by 832
Abstract
Endothelial cells in steady laminar flow assume a healthy, quiescent phenotype, while endothelial cells in oscillating disturbed flow become dysfunctional. Since endothelial dysfunction leads to atherosclerosis and cardiovascular disease, it is important to understand the mechanisms by which endothelial cells change their function [...] Read more.
Endothelial cells in steady laminar flow assume a healthy, quiescent phenotype, while endothelial cells in oscillating disturbed flow become dysfunctional. Since endothelial dysfunction leads to atherosclerosis and cardiovascular disease, it is important to understand the mechanisms by which endothelial cells change their function in varied flow environments. Endothelial metabolism has recently been proven a powerful tool to regulate vascular function. Endothelial cells generate most of their energy from glycolysis, and steady laminar flow may reduce endothelial glycolytic flux. We hypothesized that steady laminar but not oscillating disturbed flow would reduce glycolytic flux and alter glycolytic side branch pathways. In this study, we exposed human umbilical vein endothelial cells to static culture, steady laminar flow (20 dynes/cm2 shear stress), or oscillating disturbed flow (4 ± 6 dynes/cm2 shear stress) for 24 h using a cone-and-plate device. We then measured glucose and lactate uptake and secretion, respectively, and glycolytic metabolites. Finally, we explored changes in the expression and protein levels of endothelial glycolytic enzymes. Our data show that endothelial cells in steady laminar flow had decreased glucose uptake and 13C labeling of glycolytic metabolites while cells in oscillating disturbed flow did not. Steady laminar flow did not significantly change glycolytic enzyme gene or protein expression, suggesting that glycolysis may be altered through enzyme activity. Flow also modulated glycolytic side branch pathways involved in proteoglycan and glycosaminoglycan synthesis, as well as oxidative stress. These flow-induced changes in endothelial glucose metabolism may impact the atheroprone endothelial phenotype in oscillating disturbed flow. Full article
(This article belongs to the Special Issue Molecular Research of Hematological Changes in Cardiovascular Diseases)
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12 pages, 904 KiB  
Article
Leukotriene A4 Hydrolase and Hepatocyte Growth Factor Are Risk Factors of Sudden Cardiac Death Due to First-Ever Myocardial Infarction
by Fredrik Landfors, Simon Vikström, Patrik Wennberg, Jan-Håkan Jansson, Jonas Andersson and Elin Chorell
Int. J. Mol. Sci. 2022, 23(18), 10251; https://doi.org/10.3390/ijms231810251 - 6 Sep 2022
Cited by 1 | Viewed by 1458
Abstract
Patients at a high risk for sudden cardiac death (SCD) without previous history of cardiovascular disease remain a challenge to identify. Atherosclerosis and prothrombotic states involve inflammation and non-cardiac tissue damage that may play active roles in SCD development. Therefore, we hypothesized that [...] Read more.
Patients at a high risk for sudden cardiac death (SCD) without previous history of cardiovascular disease remain a challenge to identify. Atherosclerosis and prothrombotic states involve inflammation and non-cardiac tissue damage that may play active roles in SCD development. Therefore, we hypothesized that circulating proteins implicated in inflammation and tissue damage are linked to the future risk of SCD. We conducted a prospective nested case–control study of SCD cases with verified myocardial infarction (N = 224) and matched controls without myocardial infarction (N = 224), aged 60 ± 10 years time and median time to event was 8 years. Protein concentrations (N = 122) were measured using a proximity extension immunoassay. The analyses revealed 14 proteins significantly associated with an increased risk of SCD, from which two remained significant after adjusting for smoking status, systolic blood pressure, BMI, cholesterol, and glucose levels. We identified leukotriene A4 hydrolase (LTA4H, odds ratio 1.80, corrected confidence interval (CIcorr) 1.02–3.17) and hepatocyte growth factor (HGF; odds ratio 1.81, CIcorr 1.06–3.11) as independent risk markers of SCD. Elevated LTA4H may reflect increased systemic and pulmonary neutrophilic inflammatory processes that can contribute to atherosclerotic plaque instability. Increased HGF levels are linked to obesity-related metabolic disturbances that are more prevalent in SCD cases than the controls. Full article
(This article belongs to the Special Issue Molecular Research of Hematological Changes in Cardiovascular Diseases)
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