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Volume 23
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10.3390/ijms231810326
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Article

Cell Contact with Endothelial Cells Favors the In Vitro Maintenance of Human Chronic Myeloid Leukemia Stem and Progenitor Cells

by
Patricia Torres-Barrera
1,2,
Dafne Moreno-Lorenzana
3,
José Antonio Alvarado-Moreno
4,
Elena García-Ruiz
5,
Cesar Lagunas
6,
Hector Mayani
7 and
Antonieta Chávez-González
1,*
1
Laboratorio de Células Troncales Leucémicas, Unidad de Investigación Médica en Enfermedades Oncológicas, CMN Siglo XXI, Instituto Mexicano del Seguro Social, CDMX 06725, Mexico
2
Posgrado en Ciencias Biológicas, UNAM, CDMX 04510, Mexico
3
CONACYT-Instituto Nacional de Pediatria, CDMX 04530, Mexico
4
Unidad de Investigación Médica en Trombosis Hemostasia y Aterogenesis, Instituto Mexicano del Seguro Social, CDMX 03100, Mexico
5
Departamento de Hematología, Hospital de Especialidades, CMN La Raza, Instituto Mexicano del Seguro Social, CDMX 02990, Mexico
6
Departamento de Cirugías de Cadera, Hospital General “Villa Coapa” Instituto Mexicano del Seguro Social, CDMX 14310, Mexico
7
Laboratorio de Células Troncales Hematopoyéticas, Unidad de Investigación Médica en Enfermedades Oncológicas, CMN Siglo XXI, Instituto Mexicano del Seguro Social, CDMX 06725, Mexico
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2022, 23(18), 10326; https://doi.org/10.3390/ijms231810326
Submission received: 25 May 2022 / Revised: 30 July 2022 / Accepted: 26 August 2022 / Published: 7 September 2022
(This article belongs to the Special Issue Intercellular Communications in Tumor Microenvironment)
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Abstract

Chronic Myeloid Leukemia (CML) originates in a leukemic stem cell that resides in the bone marrow microenvironment, where they coexist with cellular and non-cellular elements. The vascular microenvironment has been identified as an important element in CML development since an increase in the vascularization has been suggested to be related with poor prognosis; also, using murine models, it has been reported that bone marrow endothelium can regulate the quiescence and proliferation of leukemic stem and progenitor cells. This observation, however, has not been evaluated in primary human cells. In this report, we used a co-culture of primitive (progenitor and stem) CML cells with endothelial colony forming cells (ECFC) as an in vitro model to evaluate the effects of the vascular microenvironment in the leukemic hematopoiesis. Our results show that this interaction allows the in vitro maintenance of primitive CML cells through an inflammatory microenvironment able to regulate the proliferation of progenitor cells and the permanence in a quiescent state of leukemic stem cells.
Keywords: Leukemic Stem Cells; CML; Microenvironment; Endothelial Cells Leukemic Stem Cells; CML; Microenvironment; Endothelial Cells

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MDPI and ACS Style

Torres-Barrera, P.; Moreno-Lorenzana, D.; Alvarado-Moreno, J.A.; García-Ruiz, E.; Lagunas, C.; Mayani, H.; Chávez-González, A. Cell Contact with Endothelial Cells Favors the In Vitro Maintenance of Human Chronic Myeloid Leukemia Stem and Progenitor Cells. Int. J. Mol. Sci. 2022, 23, 10326. https://doi.org/10.3390/ijms231810326

AMA Style

Torres-Barrera P, Moreno-Lorenzana D, Alvarado-Moreno JA, García-Ruiz E, Lagunas C, Mayani H, Chávez-González A. Cell Contact with Endothelial Cells Favors the In Vitro Maintenance of Human Chronic Myeloid Leukemia Stem and Progenitor Cells. International Journal of Molecular Sciences. 2022; 23(18):10326. https://doi.org/10.3390/ijms231810326

Chicago/Turabian Style

Torres-Barrera, Patricia, Dafne Moreno-Lorenzana, José Antonio Alvarado-Moreno, Elena García-Ruiz, Cesar Lagunas, Hector Mayani, and Antonieta Chávez-González. 2022. "Cell Contact with Endothelial Cells Favors the In Vitro Maintenance of Human Chronic Myeloid Leukemia Stem and Progenitor Cells" International Journal of Molecular Sciences 23, no. 18: 10326. https://doi.org/10.3390/ijms231810326

APA Style

Torres-Barrera, P., Moreno-Lorenzana, D., Alvarado-Moreno, J. A., García-Ruiz, E., Lagunas, C., Mayani, H., & Chávez-González, A. (2022). Cell Contact with Endothelial Cells Favors the In Vitro Maintenance of Human Chronic Myeloid Leukemia Stem and Progenitor Cells. International Journal of Molecular Sciences, 23(18), 10326. https://doi.org/10.3390/ijms231810326

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