Next Article in Journal
Genome-Wide Identification of the AGC Protein Kinase Gene Family Related to Photosynthesis in Rice (Oryza sativa)
Next Article in Special Issue
Phenethyl Isothiocyanate-Conjugated Chitosan Oligosaccharide Nanophotosensitizers for Photodynamic Treatment of Human Cancer Cells
Previous Article in Journal
Development of a Method for Producing oxLDL: Characterization of Their Effects on HPV-Positive Head and Neck Cancer Cells
Previous Article in Special Issue
Radiovaccination Strategy for Cancer Treatment Integrating Photodynamic Therapy-Generated Vaccines with Radiotherapy
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 23
Issue 20
10.3390/ijms232012556
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Chemiluminescence in Combination with Organic Photosensitizers: Beyond the Light Penetration Depth Limit of Photodynamic Therapy

by
Jie Gao
1,2,3,*,
Zhengjun Chen
1,2,3,
Xinmin Li
1,2,3,
Mingyan Yang
1,2,3,
Jiajia Lv
1,2,3,
Hongyu Li
1,2,3 and
Zeli Yuan
1,2,3,*
1
Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, No.6 West Xuefu Road, Xinpu District, Zunyi 563000, China
2
Key Laboratory of Biocatalysis & Chiral Drug Synthesis of Guizhou Province, School of Pharmacy, Zunyi Medical University, No.6 West Xuefu Road, Xinpu District, Zunyi 563000, China
3
Guizhou International Scientific and Technological Cooperation Base for Medical Photo-Theranostics Technology and Innovative Drug Development, Zunyi Medical University, No.6 West Xuefu Road, Xinpu District, Zunyi 563000, China
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2022, 23(20), 12556; https://doi.org/10.3390/ijms232012556
Submission received: 18 September 2022 / Revised: 5 October 2022 / Accepted: 18 October 2022 / Published: 19 October 2022
(This article belongs to the Special Issue Photodynamic Therapy and Photodetection)
Browse Figures
Versions Notes

Abstract

Photodynamic therapy (PDT) is a promising noninvasive medical technology that has been approved for the treatment of a variety of diseases, including bacterial and fungal infections, skin diseases, and several types of cancer. In recent decades, many photosensitizers have been developed and applied in PDT. However, PDT is still limited by light penetration depth, although many near-infrared photosensitizers have emerged. The chemiluminescence-mediated PDT (CL-PDT) system has recently received attention because it does not require an external light source to achieve targeted PDT. This review focuses on the rational design of organic CL-PDT systems. Specifically, PDT types, light wavelength, the chemiluminescence concept and principle, and the design of CL-PDT systems are introduced. Furthermore, chemiluminescent fraction examples, strategies for combining chemiluminescence with PDT, and current cellular and animal applications are highlighted. Finally, the current challenges and possible solutions to CL-PDT systems are discussed.
Keywords: chemiluminescence; photodynamic therapy; photosensitizer; chemiluminescence resonance energy transfer; reactive oxygen species chemiluminescence; photodynamic therapy; photosensitizer; chemiluminescence resonance energy transfer; reactive oxygen species

Share and Cite

MDPI and ACS Style

Gao, J.; Chen, Z.; Li, X.; Yang, M.; Lv, J.; Li, H.; Yuan, Z. Chemiluminescence in Combination with Organic Photosensitizers: Beyond the Light Penetration Depth Limit of Photodynamic Therapy. Int. J. Mol. Sci. 2022, 23, 12556. https://doi.org/10.3390/ijms232012556

AMA Style

Gao J, Chen Z, Li X, Yang M, Lv J, Li H, Yuan Z. Chemiluminescence in Combination with Organic Photosensitizers: Beyond the Light Penetration Depth Limit of Photodynamic Therapy. International Journal of Molecular Sciences. 2022; 23(20):12556. https://doi.org/10.3390/ijms232012556

Chicago/Turabian Style

Gao, Jie, Zhengjun Chen, Xinmin Li, Mingyan Yang, Jiajia Lv, Hongyu Li, and Zeli Yuan. 2022. "Chemiluminescence in Combination with Organic Photosensitizers: Beyond the Light Penetration Depth Limit of Photodynamic Therapy" International Journal of Molecular Sciences 23, no. 20: 12556. https://doi.org/10.3390/ijms232012556

APA Style

Gao, J., Chen, Z., Li, X., Yang, M., Lv, J., Li, H., & Yuan, Z. (2022). Chemiluminescence in Combination with Organic Photosensitizers: Beyond the Light Penetration Depth Limit of Photodynamic Therapy. International Journal of Molecular Sciences, 23(20), 12556. https://doi.org/10.3390/ijms232012556

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop