Thyroxine Regulates the Opening of the Organ of Corti through Affecting P-Cadherin and Acetylated Microtubule
Abstract
:1. Introduction
2. Results
2.1. Normal Opening of the TC and Early Opening Promoted by T3
2.2. The Ultrastructure of PCs Changes Significantly after T3 Administration
2.3. T3 Promotes the Separation of IPCs and OPCs by Affecting P-Cadherin Transfer into the Cytoplasm from the Cell Membrane
2.4. E-Cadherin and N-Cadherin Do Not Change Significantly during Opening of the TC
2.5. T3 influences the Growth of PCs via Acetylated α-Tubulin
3. Discussion
4. Materials and Methods
4.1. Animals and Models
4.2. Immunofluorescent Labelling and Confocal Image Analysis
4.3. Resin Sections and Transmission Electron Microscopy
4.4. RNA Preparation and Quantitative RT-PCR
4.5. Data Analysis
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Zhang, H.; Xie, L.; Chen, S.; Qiu, Y.; Sun, Y.; Kong, W. Thyroxine Regulates the Opening of the Organ of Corti through Affecting P-Cadherin and Acetylated Microtubule. Int. J. Mol. Sci. 2022, 23, 13339. https://doi.org/10.3390/ijms232113339
Zhang H, Xie L, Chen S, Qiu Y, Sun Y, Kong W. Thyroxine Regulates the Opening of the Organ of Corti through Affecting P-Cadherin and Acetylated Microtubule. International Journal of Molecular Sciences. 2022; 23(21):13339. https://doi.org/10.3390/ijms232113339
Chicago/Turabian StyleZhang, Huimin, Le Xie, Sen Chen, Yue Qiu, Yu Sun, and Weijia Kong. 2022. "Thyroxine Regulates the Opening of the Organ of Corti through Affecting P-Cadherin and Acetylated Microtubule" International Journal of Molecular Sciences 23, no. 21: 13339. https://doi.org/10.3390/ijms232113339