Insight into Isomeric Diversity of Glycated Amino Acids in Maillard Reaction Mixtures
Abstract
:1. Introduction
2. Results
2.1. Convenient Generation of Mono- and Diglycated Amino Acids Using a Mechanochemical Approach
2.2. Diagnostic MS/MS Fragmentation Patterns for Distinguishing Schiff Base and Amadori Isomers of Mono- and Diglycated Amino Acids
2.3. Application of Diagnostic MS/MS Fragmentations for the Identification of Glycated Amino Acid Isomers
3. Discussion
4. Materials and Methods
4.1. Materials
4.2. Sample Preparation
4.3. Electrospray Ionization/Quadrupole Time of Flight/Mass Spectrometry (ESI/QqTOF/MS)
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
ARP | Amadori rearrangement product |
CID | Collision-induced disassociation |
ESI/QqTOF/MS | Electrospray ionization/quadrupole time of flight/mass spectrometry |
HRMS | High-resolution mass spectrometry |
MRM | Multiple reaction monitoring |
MS/MS | Tandem mass spectrometry |
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Xing, H.; Yaylayan, V. Insight into Isomeric Diversity of Glycated Amino Acids in Maillard Reaction Mixtures. Int. J. Mol. Sci. 2022, 23, 3430. https://doi.org/10.3390/ijms23073430
Xing H, Yaylayan V. Insight into Isomeric Diversity of Glycated Amino Acids in Maillard Reaction Mixtures. International Journal of Molecular Sciences. 2022; 23(7):3430. https://doi.org/10.3390/ijms23073430
Chicago/Turabian StyleXing, Haoran, and Varoujan Yaylayan. 2022. "Insight into Isomeric Diversity of Glycated Amino Acids in Maillard Reaction Mixtures" International Journal of Molecular Sciences 23, no. 7: 3430. https://doi.org/10.3390/ijms23073430