Neuronal and Glial Communication via Non-Coding RNAs: Messages in Extracellular Vesicles
Abstract
:1. Introduction
2. Effect of NSC-Derived ncRNAs on Neurogenesis
3. Role of Neuronal EV-Derived ncRNAs in Neuron-to-Glia Communication
3.1. Effect of Neuron-Derived ncRNAs on Microglia Functions
Source | Recipient Cells | Neuronal ncRNAs | ncRNA Targets | Mechanism of Action | Reference |
---|---|---|---|---|---|
Mouse cortical neurons | Mouse microglia | miR-124-3p | CEBPα-PU.1 and NFκB | Microglia deactivation in the normal CNS | [28] |
Mouse neurons | Mouse microglia | miR-124-3p | MYH9 and NFκB | Suppressing microglia activation in SCI | [30] |
Rat PC12 cells | Mouse microglial BV2 cell line | miR-9-5p | SOCS2 | Promotion of the M1 phenotype in MDD | [31] |
Mouse cortical neurons | Mouse cortical astrocytes | miR-124-3p | GLT1-binding miRs, CREB | Regulation of synaptic functions in CNS | [32] |
Mouse NSC-34 neuronal cell line | Mouse cortical astrocytes | miR-218-5p | GLT1 | Alteration of glutamate uptake and astrogliosis | [33] |
Rat cortical neurons | Rat cortical astrocytes | miR-181c-3p | CXCL1 | Reduction of neuroinflammation | [34] |
Mouse CATH.a neuronal cell line | Mouse C8-D1A astrocytic cell line | lncRNA H19 | miR-18a/VEGF axis | Alteration of BBB permeability | [35] |
3.2. Effect of Neuron-Derived ncRNAs on Astrocyte Functions
3.3. Effect of Neuron-Derived ncRNAs on Oligodendrocytes
4. Role of Glial EV-Derived ncRNAs in Cell-to-Cell Communication
4.1. Effect of Microglial EV-Derived ncRNAs on Neuroinflammation
4.2. Effect of Astrocytic EV-Derived ncRNAs on Neuroinflammation
4.3. Effect of Oligodendroglial EV-Derived ncRNAs on Neuroinflammation
Source | Recipient Cells | ncRNAs | ncRNA TARGETS | Mechanism of Action | Reference |
---|---|---|---|---|---|
Rat hippocampal and cortical microglia | Rat hippocampal neurons | miR-146a-5p miR-181a miR-223-3p | Nlg1, GluR2, and GluN2B | Synaptic strength impairment | [59] |
BV-2 microglial cell line | Rat cortical oligodendrocytes | miR-23a-5p | Olig3 | Survival and maturation under oxygen-glucose deprivation (OGD), and white matter repair after mouse tMCAO ischemic model | [60] |
BV-2 microglial cell line | Mouse cortical neurons | miR-124-3p | PDE4B | Inhibited neuroinflammation in s scratch-injury model | [46] |
BV-2 microglial cell line | Mouse cortical astrocytes | miR-124 | STAT3 | Reduction of glial scar under oxygen-glucose deprivation, and reduction of infarct volume after mouse tMCAO ischemic model | [61] |
Microglia derived EVs from rat serum | Neurons from rat hippocampal slices | miR-146a-5p circANKS1B | KLF4 and CDKL5 | Suppression of neurogenesis, and synaptic impairment in chronic unpredictable mild stress (CUMS) model | [62] |
BV-2 microglial cell line | HT22 mouse hippocampal neuronal cell line, mouse neurons | miR-124-3p | Rela (p65) | Inhibition of neurodegeneration and improvement of cognitive function in repetitive mild traumatic brain injury (rmTBI) | [49] |
BV-2 microglial cell line | Mouse cortical neurons | miR-137 | Notch1 | Increased viability and reduction of apoptosis after mouse transient middle cerebral artery occlusion (tMCAO) ischemic model | [65] |
BV-2 microglial cell line | HT22 mouse hippocampal neuronal cell line, mouse neurons | miR-124-3p | FIP200 | Inhibition of autophagy | [68] |
Rat cortical astrocytes | Mouse hippocampal and cortical neurons | miR-125a-5p miR-16-5p | NTRK3 | Reduction of dendritic growth and complexity in Parkinson’s disease (PD) model | [70] |
Rat cortical astrocytes | Rat dopaminergic neurons | miR-34a | Bcl-2 | Enhanced vulnerability of dopaminergic neurons to neurotoxin in PD model | [73] |
Human induced astrocytes | Mouse Hb9-GFP motor neurons | miR-494-3p | Semaphorin 3A | Sustainment of survival and protection of neurites | [74] |
Mouse cortical astrocytes | HT22 mouse hippocampal neuronal cell line | miR-190b | ATG7 | Reduction of apoptosis and inhibition of autophagy after OGD | [75] |
Human astrocytic cell line A172, mouse whole brain astrocytes | BV-2 microglial cell line, Mouse cortical microglia | lincRNA-Cox2 | Toll-like receptors and NFκB | Restores phagocytic activity in vitro and in mice treated with morphine | [78] |
Human cortical astrocytes | Human neurons | NKILA | miR-195, NFκB and NLRX1 | Increases cell proliferation; attenuation of apoptosis and injury in mice submitted to TBI | [77] |
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Marangon, D.; Castro e Silva, J.H.; Lecca, D. Neuronal and Glial Communication via Non-Coding RNAs: Messages in Extracellular Vesicles. Int. J. Mol. Sci. 2023, 24, 470. https://doi.org/10.3390/ijms24010470
Marangon D, Castro e Silva JH, Lecca D. Neuronal and Glial Communication via Non-Coding RNAs: Messages in Extracellular Vesicles. International Journal of Molecular Sciences. 2023; 24(1):470. https://doi.org/10.3390/ijms24010470
Chicago/Turabian StyleMarangon, Davide, Juliana Helena Castro e Silva, and Davide Lecca. 2023. "Neuronal and Glial Communication via Non-Coding RNAs: Messages in Extracellular Vesicles" International Journal of Molecular Sciences 24, no. 1: 470. https://doi.org/10.3390/ijms24010470