Effect of Organic Selenium on the Homeostasis of Trace Elements, Lipid Peroxidation, and mRNA Expression of Antioxidant Proteins in Mouse Organs
Abstract
:1. Introduction
2. Results
2.1. Evaluation of Selenium Effect on Body Weight and Relative Organ Mass Index of Mice
2.2. Evaluation of Selenium, Iron, Zinc, and Copper Concentrations in Mouse Tissues
2.3. Evaluation of Malondialdehyde Content in Mouse Tissues after Exposure to Selenomethionine
2.4. Determination of Mouse Brain and Liver Catalase Activity after Exposure to Selenomethionine
2.5. Determination of mRNA Expression in Mouse Liver and Brain of Antioxidative Proteins after Exposure to Selenomethionine
3. Discussion
4. Materials and Methods
4.1. Chemicals and Reagents
4.2. Animals and Experimental Procedure
4.3. Determination of Malondialdehyde Content
4.4. Determination of Trace Element Concentrations
4.5. Preparation of the Brain and Liver Homogenates
4.6. Protein Concentration Assay
4.7. Measurement of Enzyme Catalase Activity
4.8. RNA Extraction and Real-Time Quantitative Reverse Transcription (RT) PCR (RT-qPCR)
4.9. Statistical Analysis
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Mouse Group | Trace Element | Blood (µg/L Se) (mg/L Fe, Cu, Zn) | Brain (µg/g) | Liver (µg/g) |
---|---|---|---|---|
Control | Selenium (Se) | 210.508 ± 24.138 | 0.061 ± 0.012 | 0.615 ± 0.095 |
SeMet | 2526.303 ± 181.058 * | 2.573 ± 0.147 * | 9.490 ± 0.331 * | |
Control | Iron (Fe) | 706.097 ± 32.350 | 27.265 ± 1.895 | 119.068 ± 11.259 |
SeMet | 497.121 ± 9.849 * | 38.803 ± 2.157 * | 272.894 ± 9.521 * | |
Control | Copper (Cu) | 0.985 ± 0.064 | 3.715 ± 0.164 | 7.795 ± 0.416 |
SeMet | 0.594 ± 0.026 * | 6.266 ± 0.581 * | 6.877 ±0.125 * | |
Control | Zinc (Zn) | 6.640 ± 0.294 | 16.863 ± 0.505 | 32.453 ± 1.403 |
SeMet | 6.307 ± 0.219 | 24.624 ± 2.389 * | 24.624 ± 2.389 * |
Genes | Forward Primer, 5′-3′ | Reverse Primer, 5′-3′ |
---|---|---|
Sod1 | AGCATGGCGATGAAAGCGG | CCTGCACTGGTACAGCCTTGT |
Cat | AAGATTGCCTTCTCCGGGTG | GACATCAGGTCTCTGCGAGG |
SelenoP | GAAACTGTTCAGGGGCTTGC | CACATTGCTGAGGTTGTCCTCG |
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Staneviciene, I.; Levinas, D.; Sadauskiene, I.; Liekis, A.; Viezeliene, D.; Kursvietiene, L.; Naginiene, R.; Baranauskiene, D.; Simakauskiene, V.; Vaitkiene, P.; et al. Effect of Organic Selenium on the Homeostasis of Trace Elements, Lipid Peroxidation, and mRNA Expression of Antioxidant Proteins in Mouse Organs. Int. J. Mol. Sci. 2023, 24, 9704. https://doi.org/10.3390/ijms24119704
Staneviciene I, Levinas D, Sadauskiene I, Liekis A, Viezeliene D, Kursvietiene L, Naginiene R, Baranauskiene D, Simakauskiene V, Vaitkiene P, et al. Effect of Organic Selenium on the Homeostasis of Trace Elements, Lipid Peroxidation, and mRNA Expression of Antioxidant Proteins in Mouse Organs. International Journal of Molecular Sciences. 2023; 24(11):9704. https://doi.org/10.3390/ijms24119704
Chicago/Turabian StyleStaneviciene, Inga, Dovydas Levinas, Ilona Sadauskiene, Arunas Liekis, Dale Viezeliene, Lolita Kursvietiene, Rima Naginiene, Dale Baranauskiene, Vaida Simakauskiene, Paulina Vaitkiene, and et al. 2023. "Effect of Organic Selenium on the Homeostasis of Trace Elements, Lipid Peroxidation, and mRNA Expression of Antioxidant Proteins in Mouse Organs" International Journal of Molecular Sciences 24, no. 11: 9704. https://doi.org/10.3390/ijms24119704