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Article

Albumin Is a Component of the Esterase Status of Human Blood Plasma

by
Daria A. Belinskaia
1,
Polina A. Voronina
1,
Polina I. Popova
2,
Natalia G. Voitenko
1,
Vladimir I. Shmurak
1,
Mikhail A. Vovk
3,
Tatiana I. Baranova
4,
Anastasia A. Batalova
1,
Ekaterina A. Korf
1,
Pavel V. Avdonin
5,
Richard O. Jenkins
6 and
Nikolay V. Goncharov
1,*
1
Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, pr. Torez 44, 194223 St. Petersburg, Russia
2
City Polyclinic No. 112, 25 Academician Baykov Str., 195427 St. Petersburg, Russia
3
Centre for Magnetic Resonance, St. Petersburg State University, Universitetskij pr., 26, Peterhof, 198504 St. Petersburg, Russia
4
Faculty of Biology, St. Petersburg State University, 7-9 Universitetskaya Emb., 199034 St. Petersburg, Russia
5
Koltsov Institute of Developmental Biology, Russian Academy of Sciences, 26 Vavilova Str., 119334 Moscow, Russia
6
Leicester School of Allied Health Sciences, De Montfort University, The Gateway, Leicester LE1 9BH, UK
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(12), 10383; https://doi.org/10.3390/ijms241210383
Submission received: 28 February 2023 / Revised: 13 April 2023 / Accepted: 14 June 2023 / Published: 20 June 2023
(This article belongs to the Special Issue Serum Albumin in Health and Disease: From Comparative Biochemistry to Translational Medicine)
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Abstract

The esterase status of blood plasma can claim to be one of the universal markers of various diseases; therefore, it deserves attention when searching for markers of the severity of COVID-19 and other infectious and non-infectious pathologies. When analyzing the esterase status of blood plasma, the esterase activity of serum albumin, which is the major protein in the blood of mammals, should not be ignored. The purpose of this study is to expand understanding of the esterase status of blood plasma and to evaluate the relationship of the esterase status, which includes information on the amount and enzymatic activity of human serum albumin (HSA), with other biochemical parameters of human blood, using the example of surviving and deceased patients with confirmed COVID-19. In experiments in vitro and in silico, the activity of human plasma and pure HSA towards various substrates was studied, and the effect of various inhibitors on this activity was tested. Then, a comparative analysis of the esterase status and a number of basic biochemical parameters of the blood plasma of healthy subjects and patients with confirmed COVID-19 was performed. Statistically significant differences have been found in esterase status and biochemical indices (including albumin levels) between healthy subjects and patients with COVID-19, as well as between surviving and deceased patients. Additional evidence has been obtained for the importance of albumin as a diagnostic marker. Of particular interest is a new index, [Urea] × [MDA] × 1000/(BChEb × [ALB]), which in the group of deceased patients was 10 times higher than in the group of survivors and 26 times higher than the value in the group of apparently healthy elderly subjects.
Keywords: albumin; biomarker; cholinesterase; carboxylesterase; COVID-19; diagnostics; esterase status albumin; biomarker; cholinesterase; carboxylesterase; COVID-19; diagnostics; esterase status

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MDPI and ACS Style

Belinskaia, D.A.; Voronina, P.A.; Popova, P.I.; Voitenko, N.G.; Shmurak, V.I.; Vovk, M.A.; Baranova, T.I.; Batalova, A.A.; Korf, E.A.; Avdonin, P.V.; et al. Albumin Is a Component of the Esterase Status of Human Blood Plasma. Int. J. Mol. Sci. 2023, 24, 10383. https://doi.org/10.3390/ijms241210383

AMA Style

Belinskaia DA, Voronina PA, Popova PI, Voitenko NG, Shmurak VI, Vovk MA, Baranova TI, Batalova AA, Korf EA, Avdonin PV, et al. Albumin Is a Component of the Esterase Status of Human Blood Plasma. International Journal of Molecular Sciences. 2023; 24(12):10383. https://doi.org/10.3390/ijms241210383

Chicago/Turabian Style

Belinskaia, Daria A., Polina A. Voronina, Polina I. Popova, Natalia G. Voitenko, Vladimir I. Shmurak, Mikhail A. Vovk, Tatiana I. Baranova, Anastasia A. Batalova, Ekaterina A. Korf, Pavel V. Avdonin, and et al. 2023. "Albumin Is a Component of the Esterase Status of Human Blood Plasma" International Journal of Molecular Sciences 24, no. 12: 10383. https://doi.org/10.3390/ijms241210383

APA Style

Belinskaia, D. A., Voronina, P. A., Popova, P. I., Voitenko, N. G., Shmurak, V. I., Vovk, M. A., Baranova, T. I., Batalova, A. A., Korf, E. A., Avdonin, P. V., Jenkins, R. O., & Goncharov, N. V. (2023). Albumin Is a Component of the Esterase Status of Human Blood Plasma. International Journal of Molecular Sciences, 24(12), 10383. https://doi.org/10.3390/ijms241210383

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