Involvement of Innate Immune System in the Pathogenesis of Sepsis-Associated Acute Kidney Injury
Abstract
:1. Introduction
2. Results and Discussion
3. Materials and Methods
3.1. Patients and Their Clinical and Laboratory Data
3.2. Measurements of Serum TNF-α, Circulating Immune Complexes (CIC), and Serum Complement Components
3.3. Flow Cytometry
3.4. Evaluation of Phagocytic Activity
3.5. Statistical Analysis
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Data | |
---|---|
Number | 19 |
Age (years) | 71.3 ± 2.2 |
Sex (M/F) | 12/7 |
Serum creatinine at enrollment (mg/dL) | 3.66 ± 0.40 |
SOFA score | 12.8 ± 0.8 |
Mean blood pressure (mmHg) | 64.0 ± 2.1 |
Vasopressor use | 100% |
Isolated organism (GPC/GNR/other) | 5/15/0 |
Site of infection (GI/UTI/lung/skin) | 10/4/2/1 |
AN69 ST membrane use | 68.4% |
Polymyxin B hemoperfusion treatment | 15.8% |
CRP (mg/dL) | 18.2 ± 2.1 |
Procalcitonin (ng/mL) | 74.4 ± 21.0 |
TNF-α (pg/mL) | 22.3 ± 5.4 |
CIC-mRF (≧4.2 μg/mL) | 40% |
C3 (mg/dL) | 81.6 ± 10.1 |
C4 (mg/dL) | 19.6 ± 1.8 |
C5a (ng/mL) | 24.1 ± 4.5 |
C5b-9 (ng/mL) | 2201 ± 678 |
Healthy Controls | Day 0 | Day 1 | Day 2 | |
---|---|---|---|---|
C5a (ng/mL) | 13.2 ± 1.4 * | 24.1 ± 4.5 | 20.6 ± 7.5 | 22.8 ± 6.1 |
C5b-9 (ng/mL) | 1046 ± 181 * | 2201 ± 678 | 2326 ± 1077 | 2214 ± 960 |
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Uchida, T.; Yamada, M.; Inoue, D.; Kojima, T.; Yoshikawa, N.; Suda, S.; Kamohara, H.; Oda, T. Involvement of Innate Immune System in the Pathogenesis of Sepsis-Associated Acute Kidney Injury. Int. J. Mol. Sci. 2023, 24, 12465. https://doi.org/10.3390/ijms241512465
Uchida T, Yamada M, Inoue D, Kojima T, Yoshikawa N, Suda S, Kamohara H, Oda T. Involvement of Innate Immune System in the Pathogenesis of Sepsis-Associated Acute Kidney Injury. International Journal of Molecular Sciences. 2023; 24(15):12465. https://doi.org/10.3390/ijms241512465
Chicago/Turabian StyleUchida, Takahiro, Muneharu Yamada, Dan Inoue, Tadasu Kojima, Noriko Yoshikawa, Shingo Suda, Hidenobu Kamohara, and Takashi Oda. 2023. "Involvement of Innate Immune System in the Pathogenesis of Sepsis-Associated Acute Kidney Injury" International Journal of Molecular Sciences 24, no. 15: 12465. https://doi.org/10.3390/ijms241512465