Next Article in Journal
Osteoblast-Derived Matrix Vesicles Exhibit Exosomal Traits and a Unique Subset of microRNA: Their Caveolae-Dependent Endocytosis Results in Reduced Osteogenic Differentiation
Next Article in Special Issue
The Dynamics of Nerve Degeneration and Regeneration in a Healthy Milieu and in Diabetes
Previous Article in Journal
Blank Spots in the Map of Human Skin: The Challenge for Xenotransplantation
Previous Article in Special Issue
The Role of Sensory Innervation in Homeostatic and Injury-Induced Corneal Epithelial Renewal
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 24
Issue 16
10.3390/ijms241612771
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Advancing Nerve Regeneration: Translational Perspectives of Tacrolimus (FK506)

by
Simeon C. Daeschler
1,2,*,
Konstantin Feinberg
3,
Leila Harhaus
1,
Ulrich Kneser
1,
Tessa Gordon
4,5 and
Gregory H. Borschel
3,6
1
Department of Hand, Plastic and Reconstructive Surgery, Burn Center, Department of Plastic and Hand Surgery, University of Heidelberg, BG Trauma Hospital, D-67071 Ludwigshafen, Germany
2
Neuroscience and Mental Health Program, SickKids Research Institute, Toronto, ON M5G 1X8, Canada
3
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
4
Department of Surgery, University of Toronto, Toronto, ON M5G 2C4, Canada
5
Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, Toronto, ON M5G 2C4, Canada
6
Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(16), 12771; https://doi.org/10.3390/ijms241612771
Submission received: 13 July 2023 / Revised: 11 August 2023 / Accepted: 12 August 2023 / Published: 14 August 2023
(This article belongs to the Special Issue Plasticity of the Nervous System after Injury)
Browse Figure
Review Reports Versions Notes

Abstract

Peripheral nerve injuries have far-reaching implications for individuals and society, leading to functional impairments, prolonged rehabilitation, and substantial socioeconomic burdens. Tacrolimus, a potent immunosuppressive drug known for its neuroregenerative properties, has emerged in experimental studies as a promising candidate to accelerate nerve fiber regeneration. This review investigates the therapeutic potential of tacrolimus by exploring the postulated mechanisms of action in relation to biological barriers to nerve injury recovery. By mapping both the preclinical and clinical evidence, the benefits and drawbacks of systemic tacrolimus administration and novel delivery systems for localized tacrolimus delivery after nerve injury are elucidated. Through synthesizing the current evidence, identifying practical barriers for clinical translation, and discussing potential strategies to overcome the translational gap, this review provides insights into the translational perspectives of tacrolimus as an adjunct therapy for nerve regeneration.
Keywords: tacrolimus; FK506; nerve regeneration; nerve injury; axon regeneration; clinical translation tacrolimus; FK506; nerve regeneration; nerve injury; axon regeneration; clinical translation

Share and Cite

MDPI and ACS Style

Daeschler, S.C.; Feinberg, K.; Harhaus, L.; Kneser, U.; Gordon, T.; Borschel, G.H. Advancing Nerve Regeneration: Translational Perspectives of Tacrolimus (FK506). Int. J. Mol. Sci. 2023, 24, 12771. https://doi.org/10.3390/ijms241612771

AMA Style

Daeschler SC, Feinberg K, Harhaus L, Kneser U, Gordon T, Borschel GH. Advancing Nerve Regeneration: Translational Perspectives of Tacrolimus (FK506). International Journal of Molecular Sciences. 2023; 24(16):12771. https://doi.org/10.3390/ijms241612771

Chicago/Turabian Style

Daeschler, Simeon C., Konstantin Feinberg, Leila Harhaus, Ulrich Kneser, Tessa Gordon, and Gregory H. Borschel. 2023. "Advancing Nerve Regeneration: Translational Perspectives of Tacrolimus (FK506)" International Journal of Molecular Sciences 24, no. 16: 12771. https://doi.org/10.3390/ijms241612771

APA Style

Daeschler, S. C., Feinberg, K., Harhaus, L., Kneser, U., Gordon, T., & Borschel, G. H. (2023). Advancing Nerve Regeneration: Translational Perspectives of Tacrolimus (FK506). International Journal of Molecular Sciences, 24(16), 12771. https://doi.org/10.3390/ijms241612771

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop