Next Article in Journal
Primary Liver Cancers: Connecting the Dots of Cellular Studies and Epidemiology with Metabolomics
Next Article in Special Issue
Constitutive Androstane Receptor Agonist, TCPOBOP: Maternal Exposure Impairs the Growth and Development of Female Offspring in Mice
Previous Article in Journal
Hair Follicles as a Critical Model for Monitoring the Circadian Clock
Previous Article in Special Issue
An Inverse Agonist GSK5182 Increases Protein Stability of the Orphan Nuclear Receptor ERRγ via Inhibition of Ubiquitination
 
 
Review
Peer-Review Record

Role of FXR in Renal Physiology and Kidney Diseases

Int. J. Mol. Sci. 2023, 24(3), 2408; https://doi.org/10.3390/ijms24032408
by Yanlin Guo, Guixiang Xie and Xiaoyan Zhang *
Reviewer 1:
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2023, 24(3), 2408; https://doi.org/10.3390/ijms24032408
Submission received: 31 December 2022 / Revised: 18 January 2023 / Accepted: 23 January 2023 / Published: 26 January 2023
(This article belongs to the Special Issue Nuclear Receptors in Health and Diseases)

Round 1

Reviewer 1 Report

 

FXR have high importance in the control cell and physiological processes and description its role in the pathogenesis can be interesting for the readers and topic is suitable for IJMS. Nevertheless, some point be taken for the improvement of manuscript quality.  

Chapter 2 Table FXR protein, including variants

Chapter 4 regulation of FXR in the context cell, including schema, or figure should be added.

Chapter 6 Oncological diseases should be included.

Minor

Line 29, 82,144,1169, 174 and others uncorrected performing multiple citations

Line 165 and others missing space

Author Response

Please see the attachment

Author Response File: Author Response.docx

Reviewer 2 Report

Manuscript by Guo et al is a well-written account of current knowledge of FXR in renal physiology and kidney diseases. It will be a highly cited article in future.

Minor comments include: 1) Inclusion of references in the first paragraph – especially for the statements in lines 24 and 26. 2) Inclusion of the regulation of FXR transcription activity (including cofactors and post-translational modifications) and its impact on renal physiology.

Author Response

Please see the attachment

Author Response File: Author Response.docx

Back to TopTop