Multiparity and Aging Impact Chondrogenic and Osteogenic Potential at Symphyseal Enthesis: New Insights into Interpubic Joint Remodeling
Abstract
:1. Introduction
2. Results
2.1. Tissue Morphology and Cell Phenotype of Mouse Symphyseal Enthesis Remodeling during Pregnancy and Postpartum
2.2. Gene Expression of Chondrogenic and Osteogenic Transcription Factors at the Mouse Interpubic Joint Remodeling during Pregnancy and Postpartum
2.3. Immunolocalization of Chondrogenic and Osteogenic Markers at the Mouse Symphyseal Enthesis Remodeling during Pregnancy and Postpartum
3. Discussion
4. Materials and Methods
4.1. Animals
4.2. Light Microscopy
4.3. Transmission Electron Microscopy (TEM)
4.4. Immunohistochemistry
4.5. Real-Time PCR (qPCR)
4.6. Statistical Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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de Sousa, L.M.; Castelucci, B.G.; Suarez, P.A.S.; Damas, I.I.; Mariano, F.V.; Joazeiro, P.P.; Consonni, S.R. Multiparity and Aging Impact Chondrogenic and Osteogenic Potential at Symphyseal Enthesis: New Insights into Interpubic Joint Remodeling. Int. J. Mol. Sci. 2023, 24, 4573. https://doi.org/10.3390/ijms24054573
de Sousa LM, Castelucci BG, Suarez PAS, Damas II, Mariano FV, Joazeiro PP, Consonni SR. Multiparity and Aging Impact Chondrogenic and Osteogenic Potential at Symphyseal Enthesis: New Insights into Interpubic Joint Remodeling. International Journal of Molecular Sciences. 2023; 24(5):4573. https://doi.org/10.3390/ijms24054573
Chicago/Turabian Stylede Sousa, Lizandra Maia, Bianca Gazieri Castelucci, Paula Andrea Saenz Suarez, Ingrid Iara Damas, Fernanda Viviane Mariano, Paulo Pinto Joazeiro, and Sílvio Roberto Consonni. 2023. "Multiparity and Aging Impact Chondrogenic and Osteogenic Potential at Symphyseal Enthesis: New Insights into Interpubic Joint Remodeling" International Journal of Molecular Sciences 24, no. 5: 4573. https://doi.org/10.3390/ijms24054573