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Volume 24
Issue 8
10.3390/ijms24087147
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Review
Peer-Review Record

ABCG2 in Acute Myeloid Leukemia: Old and New Perspectives

Int. J. Mol. Sci. 2023, 24(8), 7147; https://doi.org/10.3390/ijms24087147
by Daniela Damiani 1,2,* and Mario Tiribelli 1,2
Reviewer 1:
Tadakazu Kondo
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2023, 24(8), 7147; https://doi.org/10.3390/ijms24087147
Submission received: 10 March 2023 / Revised: 5 April 2023 / Accepted: 10 April 2023 / Published: 12 April 2023
(This article belongs to the Special Issue Drug Transporter in Pathological Conditions)

Round 1

Reviewer 1 Report

This review focuses on the role of a specific MDR protein, ABCG2, in AML and summarize the the current knowledge on the impact of its expression and polymorphisms on disease outcome and possibility to improve the efficacy of anti-leukemic therapies. This comprehensive review article is informative and meaningful for hematologists.

I have no further comments.

Author Response

We thank the reviewer for his/her appreciation of our work.

Reviewer 2 Report

The review article describes the role of the ABCG2 protein responsible for inducing multidrug resistance in acute myeloid leukemia cells. Summarizing the knowledge so far may provide new strategies to overcome the negative effect of ABCG2 overexpression. The topic of the article is appropriate for the journal and the Special issue.

 

The manuscript can be improved by adding a discussion part with comments and suggestions for future therapies.

There are many grammatical and typing errors that should be corrected before the final acceptance of the paper.

Author Response

We thank the reviewer for his/her appreciaition of our work and the suggestion to improve the manuscript.

The paper has been extensively revised to improve readability and correct typos.

Most of the discussion section is dedicated to a possibile future role of ABCG2 inhibition or modulation to improve outcome of AML patients, even if, to date, many questions remain to be answered.

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