GNN Codon Adjacency Tunes Protein Translation
Abstract
:1. Introduction
2. Results and Discussion
2.1. NNU Codons Have Distinctive Properties
2.2. GNN Adjacency Slows Protein Translation
2.3. The CAR Surface Is Ideally Positioned to Mediate +1 GNN Regulation
2.4. A Sequence-Sensitive Ribosome Braking System
3. Materials and Methods
3.1. Ribosome Profiling Analysis
3.2. Molecular Dynamics Simulations
3.3. Codon Frequency and Information-Theoretic Analysis
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Sun, J.; Hwang, P.; Sakkas, E.D.; Zhou, Y.; Perez, L.; Dave, I.; Kwon, J.B.; McMahon, A.E.; Wichman, M.; Raval, M.; et al. GNN Codon Adjacency Tunes Protein Translation. Int. J. Mol. Sci. 2024, 25, 5914. https://doi.org/10.3390/ijms25115914
Sun J, Hwang P, Sakkas ED, Zhou Y, Perez L, Dave I, Kwon JB, McMahon AE, Wichman M, Raval M, et al. GNN Codon Adjacency Tunes Protein Translation. International Journal of Molecular Sciences. 2024; 25(11):5914. https://doi.org/10.3390/ijms25115914
Chicago/Turabian StyleSun, Joyce, Pete Hwang, Eric D. Sakkas, Yancheng Zhou, Luis Perez, Ishani Dave, Jack B. Kwon, Audrey E. McMahon, Mia Wichman, Mitsu Raval, and et al. 2024. "GNN Codon Adjacency Tunes Protein Translation" International Journal of Molecular Sciences 25, no. 11: 5914. https://doi.org/10.3390/ijms25115914