Ferroptosis-Regulated Natural Products and miRNAs and Their Potential Targeting to Ferroptosis and Exosome Biogenesis
Abstract
:1. Introduction
1.1. Relationship between Exosomes and Ferroptosis
1.2. Exosome-Biogenesis-Modulating Genes
1.3. Ferroptosis-Modulating Genes
1.3.1. Ferroptosis-Inducing Genes
1.3.2. Ferroptosis-Inhibiting Genes
1.4. The Knowledge Gaps of miRNA-Modulating Natural Products for the Induction and Inhibition of Ferroptosis and Exosome Biogenesis
1.5. The Novelty, Rationale, and Outline of This Review
2. Ferroptosis-Modulating Natural Products
Natural Products | Ferroptosis Modulation by Natural Products * | Ferroptosis-Inducing Genes | Ferroptosis-Inhibiting Genes | |
---|---|---|---|---|
Ferroptosis inducers | Artesunate [41] | Lymphoma | ATG5 [42], ATG7 [43], NCOA4 [44], TFRC [45] | SLC11A2 [46], FTH1 [47], GPX4 [48], SP1 [49] |
Albiziabioside A [50] | Breast Ca | GPX4 [51] | ||
Alloimperatorin [24] | Breast Ca | SLC7A11, GPX4, p-AIFM1 [24] | ||
Amentoflavone [52] | Gastric Ca | ↓ FTH1 [31], SP1 [53] | ||
Ardisiacrispin B [54] | Leukemia | |||
Aridanin [55] | Liver Ca | |||
Artemisinin [56] | Osteosarcoma | ATF3 [57] | GPX4 [58] | |
Artenimol [59] | Leukemia | |||
Auriculasin [25] | Colon Ca | pAIFM1 [25] | ||
Bromelain [60] | Colon Ca | ATG5, ATG7 [61], ACSL4 [60] | ||
Curcumin [62] | Colon Ca | ATF3 [63], ACSL4 [64], IREB2 [63], HMOX1 [65] | SLC7A11, GPX4 [62,64], HIF1A [66], NEDD4 [67,68] | |
Dihydroartemisinin [69] | Glioma | ATF4 [70,71], NCOA4 [72], HMOX1 [69] | GPX4, SLC7A11, SLC3A2 [70], FTH1 [73] | |
Dihydroisotanshinone I [74] | Glioma | ACSL4 [74] | GPX4 [74] | |
Diplacone [75] | Lung Ca | |||
DMOCPTL [76] | Breast Ca | GPX4 [76] | ||
Epigallocatechin gallate [77] | Pancreatic Ca | ATF4 [78], ATG5, ATG7 [79], YAP1 [80] | SP1, TP53 [81] | |
Epunctanone [82] | Leukemia | |||
Erianin [83] | Renal Ca stem cells | ALOX12 [83] | GPX4, FTH1, SLC7A11 [83], TP53 [84] | |
Ferroptocide [23] | Ovarian Ca | TXN [23] | ||
Gallic acid [85] | Breast Ca | ATF4 [86] | GPX4, SLC7A11 [86] | |
Heteronemin [87] | Liver Ca | ATG5, ATG7 [88] | GPX4 [87], TP53 [89,90] | |
Matrine [91] | Colon Ca | ATF4 [91] | GPX4, SLC7A11 [91] | |
Nitidine chloride [92] | Myeloma | NEDD4 [93] | ||
Piperlongumine [94] | Pancreas Ca | ATF4 [95], HMOX1 [96] | FTH1, SLC7A11, GPX4 [97], SP1 [98] | |
Pseudolaric acid B [99] | GBM | TFRC [31] | SLC7A11 [99] | |
Punicic acid [100] | Colon Ca | |||
Quercetin [101] | Breast Ca | ATF3 [102], HMOX1 [103] | SLC40A1 [104], FTL [105], SP1 [106] | |
Ruscogenin [31] | Pancreas Ca | TF [31,107] | SLC40A1 [107] | |
Salinomycin [108] | Head/neck Ca | ATF3 [109], ATF4 [110], ATG5, ATG7 [111], DPP4 [112], IREB2, TFRC [108,113] | FTH1, FTL [113], NFE2L2, GCLC [114], HIF1A [115], TP53 [116], FTH1 [108] | |
Sanguinarine [117,118] | Cervical Ca | SLC7A11 [118] | ||
Solasonine [31] | Liver Ca | GPX4, GSS [119], SLC7A11 [120] | ||
Sulforaphane [121] | Leukemia | ATF3 [122], ATG7 [123], ALOX12 [124], HMOX1 [125], YAP1 [126] | GPX4 [124], SLC7A11 [127] | |
Tagitinin C [128] | Colon Ca | HMOX1 [128] | ||
Talaroconvolutin A [22] | Colon Ca | ALOXE3 [22] | SLC7A11 [22] | |
Trigonelline [31] | Liver Ca | DPP4 [129] | NFE2L2 [129] | |
Typhaneoside [130] | Leukemia | |||
Ungeremine [131] | Leukemia | |||
Withaferin A [31] | Neuroblastoma | ATF3, ATF4, HMOX1 [132], ATG5, ATG7 [133] | GPX4, NFE2L2 [31] | |
β-Elemene [134] | Colon Ca | HIF1A [135], SP1 [136] | ||
β-Phenethyl isothiocyanate (PEITC) [137] | Osteosarcoma | ATG4 [138], HMOX1 [139] | SLC11A2, SLC40A1, FTH1 [140], GPX4, SLC11A2 [137], HIF1A [141] | |
Ferroptosis inhibitors | Nodosin [142] | Bladder Ca | AIFM2, GPX4 [142] | |
Nordihydroguaiareticacid [143] | Leukemia | ALOX12, ALOX15 [143] | ||
Cryptotanshinone [144] | Pancreas Ca | |||
Artepillin C [145] | Neuron | |||
Bakuchiol [146] | Neuron | |||
Berberine [147] | Cardiomyocytes | ATG5 [148], ACSL4 [149] | Cruloplasmin [150], NFE2L2 [151], SLC7A11 [149] | |
Glycyrrhizin [152] | Acute liver failure | GPX4 [153], SLC40A1 [154] | ||
Psoralidin [146] | Neuron | ALOX5 [146] | ||
Butein [155] | BMSCs | SP1 [156] | ||
Baicalein [157] | Pancreas Ca | ATF3 [158], ACSL4 [157], ALOX12 [159], ALOX15 [160] | GPX4 [157,161], SLC7A11 [157], GCLC [162] | |
7-O-cinnamoyl-taxifolin [163] | Neuron | NFE2L2 [163] | ||
3-Hydroxybakuchiol [146] | Neuron | |||
Morachalcone D [164] | Cardiomyocytes | SLC7A11, NFE2L2, GPX4 [164] | ||
Sterubin [165] | Neuron | NFE2L2 [165] | ||
Proanthocyanidin [166] | Spinal cord injury mice | ATG5, ATG7 [167], ACSL4 [168], DDP4 [169] | GPX4, SLC7A11 [168], NFE2L2 [151] | |
Puerarin [170] | Cardiomyocyte injury | FTH1 [31], GCLC [171], NFE2L2, GPX4 [172] |
2.1. Ferroptosis-Inducing Natural Products
2.1.1. Artesunate
2.1.2. Albiziabioside A and Alloimperatorin
2.1.3. Amentoflavone, Artemisinin, Auriculasin, and Bromelain
2.1.4. Curcumin
2.1.5. Dihydroartemisinin, Dihydroisotanshinone I, and DMOCPTL
2.1.6. Epigallocatechin Gallate (EGCG)
2.1.7. Erianin and Ferroptocide
2.1.8. Gallic Acid, Heteronemin, Matrine, Nitidine Chloride, and Sanguinarine
2.1.9. Piperlongumine and Pseudolaric Acid B
2.1.10. Quercetin
2.1.11. Ruscogenin, Sulforaphane, and Solasonine
2.1.12. Salinomycin
2.1.13. Sulforaphane
2.1.14. Tagitinin C, Talaroconvolutin A, Trigonelline, and Withaferin A
2.1.15. β-Elemene and β-Phenethyl Isothiocyanate (PEITC)
2.1.16. Other Ferroptosis-Inducing Natural Products
2.2. Ferroptosis-Inhibiting Natural Products
2.2.1. Cancer Studies for Ferroptosis-Inhibiting Natural Products
Nodosin, Nordihydroguaiaretic Acid, and Cryptotanshinone
2.2.2. Cancer and Non-Cancer Studies for Ferroptosis-Inhibiting Natural Products
Artepillin C and Bakuchiol
Berberine
Glycyrrhizin, Psoralidin, and Butein
Baicalein
2.2.3. Non-Cancer Studies for Ferroptosis-Inhibiting Natural Products
2.3. Exosome Regulation by Ferroptosis-Modulating Natural Products
3. Ferroptosis-Modulating miRNAs and Their Ferroptosis-Targeting Genes
Ferroptosis- Modulating miRNA | Cancer Cells | Targets | miRDB-Targeting Ferroptosis-Inducing/ Inhibiting Genes (Targets) | |
---|---|---|---|---|
Ferroptosis-inducing miRNAs | miR-1261 [211] | Liver Ca | SLC7A11 | |
miR-143-3p [212] | Renal Ca | SLC7A11 | ||
miR-34c-3p [213] | Oral Ca | |||
miR-382-5p [214] | Ovarian Ca | |||
miR-489-3p [215] | Gastric Ca | |||
miR-25-3p [216] | Prostate Ca | SLC7A11, AIFM1, SLC11A2 | ||
miR-409-3p [217] | Cervical Ca | SLC7A11 | ||
miR-515-5p [217] | Cervical Ca | |||
miR-545-3p [218] | Thyroid Ca | GCLC, SLC11A2 | ||
miR-27a-3p [219] | Bladder Ca | SLC7A11, NEDD4, NFE2L2 | ||
miR-375-3p [220] | Oral Ca | SLC7A11 | ||
miR-205-5p [221] | Airway epithelial * | TXNRD1 | ||
miR-302a-3p [222] | Lung Ca | SLC40A1 | SLC40A1, AIFM1 | |
miR-4735-3p [223] | Renal Ca | HIF1A, NEDD4, GCLC, SLC40A1 | ||
miR-142-3p [224] | Liver Ca | SLC3A2 | SLC7A11 | |
miR-1231 [225] | Thyroid Ca | GPX4 | BGN | |
miR-1287-5p [226] | Lung Ca | |||
miR-15a-5p [227] | Prostate Ca | SLC11A2 | ||
miR-15a-3p [228] | Colon Ca | HIF1A | ||
miR-539-5p [229] | Colon Ca | SP1, TXNRD1, SLC11A2, SLC7A11, SLC40A1 | ||
miR-541-3p [230] | Liver Ca | |||
miR-324-3p [231] | Lung Ca | SLC7A11 | ||
miR-450b-5p [232] | Liver Ca | NFE2L2, CP, SLC7A11, AIFM1 | ||
miR-125b-5p [233] | Oral Ca | NFE2L2 | AIFM1, TXNRD1 | |
miR-144-3p [234] | Leukemia | NFE2L2, SLC7A11, GCLC | ||
miR-28-5p [235] | Breast Ca | NFE2L2 | ||
miR-507 [236] | Esophageal Ca | NFE2L2 | ||
miR-29b-1-5p [237] | Breast Ca | PROM2 | ||
miR-365a-3p [238] | Liver Ca | |||
miR-214-3p [239] | Liver Ca | ATF4 | TFAP2C, GPX4 | |
miR-3200-5p [240] | Liver Ca | |||
miR-1228-3p [241] | Breast Ca | AIFM2 | ||
miR-429 [29] | Gastric Ca | BGN | ||
miR-19b-3p [242] | Lung Ca | FTH1 | SLC11A2 | |
miR-129-5p [243] | Bladder Ca | PROM2 | NFE2L2 | |
miR-101-3p [27] | Lung Ca | TBLR1 | NFE2L2, SLC7A11, GCLC | |
Ferroptosis-inhibiting miRNAs | miR-23a-3p [244] | Liver Ca | ACSL4 | EPAS1 |
miR-424-5p [245] | Ovarian Ca | ACSL4, YAP1 | ||
miR-4291 [246] | Cervical Ca | DPP4, NCOA4, YAP1 | ||
miR-670-3p [247] | GBM | ACSL4 | ||
miR-18a-5p [248] | GBM | ALOXE3 | WWTR1 | |
miR-522-3p [249] | Gastric Ca | ALOX15 | WWTR1, ACSL4 | |
miR-19a-3p [21] | Colon Ca | IREB2 | IREB2, ACSL4, NCOA4, ATG5 |
3.1. Ferroptosis-Inducing miRNAs and Their Ferroptosis-Targeting Genes
3.1.1. SLCA11 (Ferroptosis-Inhibiting Gene)
3.1.2. SLC40A1 and SLC3A2 (Ferroptosis-Inhibiting Genes)
3.1.3. GPX4 (Ferroptosis-Inhibiting Gene)
3.1.4. NFE2L2 (Ferroptosis-Inhibiting Gene)
3.1.5. ATF4 (Ferroptosis-Inhibiting Gene)
3.1.6. AIFM2, BGN, FTH1, PROM2, and TBLR1 (Ferroptosis-Inhibiting Genes)
3.2. Ferroptosis-Inhibiting miRNAs and Their Ferroptosis-Targeting Genes
3.2.1. ACSL4 (Ferroptosis-Inducing Gene)
3.2.2. ALOXE3, IREB2, and ALOX15 (Ferroptosis-Inducing Gene)
4. Ferroptosis-Modulating miRNAs and Their Exosome-Biogenesis-Targeting Genes
Ferroptosis- Modulating miRNA | Exosomal miRNA Studies | Exosome Biogenesis Genes (miRDB) | |
---|---|---|---|
Ferroptosis-inducing miRNAs | miR-101-3p [27] | Medulloblastoma [250] | RAB27A |
miR-1231 [225] | Pancreatic ca [251] | ||
miR-1287-5p [226] | Inflammatory injury [252] | RAB7A | |
miR-129-5p [243] | Colon ca [253] | VPS4B, ATP9A, PDCD6IP | |
miR-142-3p [224] | Retinoblastoma [254] | STAM, HGS | |
miR-143-3p [212] | Lung ca [255], pancreatic ca [256] | RAB7A | |
miR-144-3p [234] | Endothelial cells [257] | VPS4B, PDCD6IP, SMPD3 | |
miR-15a-5p [227] | Endometrial ca [258], lung ca [259] | MYO5B, VPS4A | |
miR-15a-3p [228] | Wound repair [260] | ||
miR-19b-3p [242] | Lung ca [261] | SDC1, VPS4B, MYO5B | |
miR-28-5p [235] | Lung injury [262] | SDC1 | |
miR-29b-1-5p [237] | COPS5 | ||
miR-302a-3p [222] | Preeclampsia [263] | SDC1, RAB11A | |
miR-3200-5p [240] | SMPD3 | ||
miR-324-3p [231] | RAB7B | ||
miR-34c-3p [213] | Lung ca [264] | CD34 | |
miR-365a-3p [238] | MYO5B | ||
miR-409-3p [217] | Mast cells [265] | STAM | |
miR-450b-5p [232] | Rat [266] | ATP9A, RAB11A, PDCD6IP | |
miR-507 [236] | RAB11A, STEAP3, PDCD6IP | ||
miR-515-5p [217] | RAB11A | ||
miR-539-5p [229] | Stem cells [267] | STAM | |
miR-545-3p [218] | RAB11A | ||
Ferroptosis- inhibiting miRNAs | miR-18a-5p [248] | Osteoblast cells [268] | |
miR-19a-3p [21] | Ischemic myocardium [269] | SDC1, VPS4B, MYO5B | |
miR-23a-3p [244] | Cholangiocarcinoma [270] | ||
miR-424-5p [245] | Endothelial cells [271] | VPS4A, MYO5B | |
miR-4291 [246] | ATP9A, SMPD3, TSG101, MYO5B | ||
miR-522-3p [249] | PDCD6IP | ||
miR-670-3p [247] | CD34, RAB27A |
4.1. The Potential Role of the Exosome Biogenesis Modulation of Ferroptosis-Inducing miRNA in Cancer Studies
4.1.1. Anticancer Effects of Ferroptosis-Inducing miRNAs
4.1.2. miRDB Targets of Ferroptosis-Inducing miRNAs
4.2. The Potential Role of the Exosome Biogenesis Modulation of Ferroptosis-Inducing miRNA in Non-Cancer Studies
4.2.1. Non-Cancer Functions of Ferroptosis-Inducing miRNAs
4.2.2. miRDB Targets of Ferroptosis-Inducing miRNAs
4.3. The Potential Role of the Exosome Biogenesis Modulation of Ferroptosis-Inhibiting miRNA in Cancer Studies
4.4. The Potential Role of the Exosome Biogenesis Modulation of Ferroptosis-Inhibiting miRNA in Non-Cancer Studies
5. Ferroptosis-Modulating miRNAs Are Associated with Some Natural Products
miRNAs | Ferroptosis-Modulating Natural Products | |
---|---|---|
Ferroptosis-inducing miRNAs | miR-101-3p | Curcumin [272] |
miR-125b-5p | PEITC [273], quercetin [274], EGCG [275], berberine [276] | |
miR-1287-5p | Curcumin [277] | |
miR-129-5p | Matrine [278] | |
miR-142-3p | Artesunate [279], quercetin [280], curcumin [281] | |
miR-143-3p | Curcumin [282], EGCG [283,284], sulforaphane [285], quercetin [286] | |
miR-144-3p | Curcumin [287] | |
miR-15a-5p | Curcumin [288], baicalin [289], Withaferin A [290] | |
miR-15a-3p | EGCG [284] | |
miR-205-5p | Cryptotanshinone ↓ [291] proanthocyanidins ↓ [292], curcumin [293] | |
miR-214-3p | EGCG [284], sulforaphane [285] | |
miR-25-3p | Withaferin A [294] | |
miR-27a-3p | β-elemene [295], quercetin [296] | |
miR-28-5p | Curcumin [297] | |
miR-302a-3p | Curcumin [298] | |
miR-324-3p | Salinomycin ↓ [299] | |
miR-365a-3p | Sulforaphane [300] | |
miR-375-3p | Solasonine [301] | |
miR-409-3p | Curcumin [302] | |
miR-429 | Curcumin [303], berberine ↓ [304,305] | |
miR-489-3p | Curcumin [306] | |
Ferroptosis- inhibiting miRNAs | miR-18a-5p | Curcumin ↓ [307] |
miR-19a-3p | Berberine [308], proanthocyanidins [292], matrine ↓ [309], Sulforaphane ↓ [310] | |
miR-23a-3p | Berberine [311] | |
miR-424-5p | Curcumin [312] | |
miR-522-3p | EGCG ↓ [284] |
5.1. Ferroptosis-Inducing miRNAs: miR-101-3p, miR-125b-5p, miR-1287-5p, and miR-129-5p
5.2. Ferroptosis-Inducing miRNAs: miR-142-3p, miR-143-3p, miR-144-3p, and miR-15a-5p
5.3. Ferroptosis-Inducing miRNAs: miR-15a-3p, miR-205-5p, miR-214-3p, and miR-27a-3p
5.4. Ferroptosis-Inducing miRNAs: miR-28-5p, miR-302a-3p, miR-365a-3p, miR-375-3p, miR-429, and miR-489
5.5. Ferroptosis-Inducing miRNAs: miR-382-5p and miR-409-3p
5.6. Ferroptosis-Inhibiting miRNAs: miR-18a-5p, miR-19a-3p, miR-23a-3p, and miR-552-3p
5.7. Natural-Product-Centric Overview Connecting to Ferroptosis-Modulating miRNAs
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
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Chuang, Y.-T.; Yen, C.-Y.; Chien, T.-M.; Chang, F.-R.; Tsai, Y.-H.; Wu, K.-C.; Tang, J.-Y.; Chang, H.-W. Ferroptosis-Regulated Natural Products and miRNAs and Their Potential Targeting to Ferroptosis and Exosome Biogenesis. Int. J. Mol. Sci. 2024, 25, 6083. https://doi.org/10.3390/ijms25116083
Chuang Y-T, Yen C-Y, Chien T-M, Chang F-R, Tsai Y-H, Wu K-C, Tang J-Y, Chang H-W. Ferroptosis-Regulated Natural Products and miRNAs and Their Potential Targeting to Ferroptosis and Exosome Biogenesis. International Journal of Molecular Sciences. 2024; 25(11):6083. https://doi.org/10.3390/ijms25116083
Chicago/Turabian StyleChuang, Ya-Ting, Ching-Yu Yen, Tsu-Ming Chien, Fang-Rong Chang, Yi-Hong Tsai, Kuo-Chuan Wu, Jen-Yang Tang, and Hsueh-Wei Chang. 2024. "Ferroptosis-Regulated Natural Products and miRNAs and Their Potential Targeting to Ferroptosis and Exosome Biogenesis" International Journal of Molecular Sciences 25, no. 11: 6083. https://doi.org/10.3390/ijms25116083