Next Article in Journal
Colonic Tuft Cells: The Less-Recognized Therapeutic Targets in Inflammatory Bowel Disease and Colorectal Cancer
Next Article in Special Issue
Special Issue “Functional Role of Cytokines in Cancer and Chronic Inflammation”
Previous Article in Journal
The Role of Bacterial Extracellular Vesicles in the Immune Response to Pathogens, and Therapeutic Opportunities
Previous Article in Special Issue
Emerging Roles of Vitamin B12 in Aging and Inflammation
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 25
Issue 11
10.3390/ijms25116211
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Galanin Coordinates Macrophage-Associated Fibro-Inflammatory Response and Mitochondrial Integrity in Myocardial Infarction Reperfusion Injury

by
Lesia Savchenko
1,2,
Solomiia Kramar
2,3,
Nika Todua
2,
Dimitri Marsal
2,
Ryeonshi Kang
2,
Audrey Swiader
2,
Nathalie Pizzinat
2 and
Oksana Kunduzova
2,*
1
Department of Internal Medicine, Poltava State Medical University, 23 Shevchenko, 36000 Poltava, Ukraine
2
National Institute of Health and Medical Research (INSERM) U1297, Paul Sabatier University, Cedex4, 31432 Toulouse, France
3
Histology and Embryology Department, I. Horbachevsky Ternopil National Medical University, 46001 Ternopil, Ukraine
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(11), 6211; https://doi.org/10.3390/ijms25116211
Submission received: 23 April 2024 / Revised: 24 May 2024 / Accepted: 30 May 2024 / Published: 5 June 2024
(This article belongs to the Special Issue Functional Role of Cytokines in Cancer and Chronic Inflammation)
Browse Figures
Versions Notes

Abstract

Myocardial infarction activates an intense fibro-inflammatory reaction that is essential for cardiac remodeling and heart failure (HF). Bioactive peptide galanin plays a critical role in regulating cardiovascular homeostasis; however, its specific functional relevance in post-infarction fibro-inflammatory reprogramming remains obscure. Here, we show that galanin coordinates the fibro-inflammatory trajectory and mitochondrial integrity in post-infarction reperfusion injury. Aberrant deposition of collagen was associated with a marked increase in CD68-positive macrophage infiltration in cardiac tissue in mice subjected to myocardial ischemia/reperfusion (I/R) for 14 days compared to sham controls. Furthermore, we found that the myocardial expression level of a specific marker of M2 macrophages, CD206, was significantly down-regulated in I/R-challenged mice. In contrast, galanin treatment started during the reperfusion phase blunted the fibro-inflammatory responses and promoted the expression of CD206 in I/R-remodeled hearts. In addition, we found that the anti-apoptotic and anti-hypertrophic effects of galanin were associated with the preservation of mitochondrial integrity and promotion of mitochondrial biogenesis. These findings depict galanin as a key arbitrator of fibro-inflammatory responses to cardiac I/R injury and offer a promising therapeutic trajectory for the treatment of post-infarct cardiovascular complications.
Keywords: inflammation; cardiac remodeling; mitochondria; apoptosis; fibrosis inflammation; cardiac remodeling; mitochondria; apoptosis; fibrosis

Share and Cite

MDPI and ACS Style

Savchenko, L.; Kramar, S.; Todua, N.; Marsal, D.; Kang, R.; Swiader, A.; Pizzinat, N.; Kunduzova, O. Galanin Coordinates Macrophage-Associated Fibro-Inflammatory Response and Mitochondrial Integrity in Myocardial Infarction Reperfusion Injury. Int. J. Mol. Sci. 2024, 25, 6211. https://doi.org/10.3390/ijms25116211

AMA Style

Savchenko L, Kramar S, Todua N, Marsal D, Kang R, Swiader A, Pizzinat N, Kunduzova O. Galanin Coordinates Macrophage-Associated Fibro-Inflammatory Response and Mitochondrial Integrity in Myocardial Infarction Reperfusion Injury. International Journal of Molecular Sciences. 2024; 25(11):6211. https://doi.org/10.3390/ijms25116211

Chicago/Turabian Style

Savchenko, Lesia, Solomiia Kramar, Nika Todua, Dimitri Marsal, Ryeonshi Kang, Audrey Swiader, Nathalie Pizzinat, and Oksana Kunduzova. 2024. "Galanin Coordinates Macrophage-Associated Fibro-Inflammatory Response and Mitochondrial Integrity in Myocardial Infarction Reperfusion Injury" International Journal of Molecular Sciences 25, no. 11: 6211. https://doi.org/10.3390/ijms25116211

APA Style

Savchenko, L., Kramar, S., Todua, N., Marsal, D., Kang, R., Swiader, A., Pizzinat, N., & Kunduzova, O. (2024). Galanin Coordinates Macrophage-Associated Fibro-Inflammatory Response and Mitochondrial Integrity in Myocardial Infarction Reperfusion Injury. International Journal of Molecular Sciences, 25(11), 6211. https://doi.org/10.3390/ijms25116211

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop