Photosealed Neurorrhaphy Using Autologous Tissue
Abstract
:1. Introduction
2. Results
2.1. Functional Recovery
2.2. Gastrocnemius Muscle Mass Retention
2.3. Histology and Histomorphometry
3. Discussion
4. Materials and Methods
4.1. Preparation of Crosslinked Human Amnion (xHAM)
4.2. Surgical Procedures
- Group 1: Standard Neurorraphy (n = 12)
- Group 2: Photosealed xHAM Wrap (n = 12).
- Group 3: Photosealed Autologous vein Wrap (n = 12).
4.3. Functional Recovery
4.4. Gastrocnemius Muscle Mass Retention
4.5. Histology and Histomorphometry
4.6. Statistical Analysis
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Group | SFI (120 Days) | % Muscle Mass | Intrafascicular Area Ratio (D/P) | Axon Diameter Ratio (D/P) |
---|---|---|---|---|
Microsurgery | −58.4 +/− 10.9 | 69 +/− 7 | 0.84 +/− 0.22 | 0.77 +/− 0.17 |
PTB/xHAM | −57.9 +/− 8.7 | 70 +/− 7 | 0.98 +/− 0.19 | 0.78 +/− 0.20 |
PTB/vein | −52.4 +/− 17.1 | 70 +/− 7 | 0.95 +/− 0.19 | 0.80 +/− 0.26 |
Group | Preop | 30 Days | 60 Days | 90 Days | 120 Days |
---|---|---|---|---|---|
Microsurgery | 19.4 +/− 1.8 | 7.9 +/− 2.2 | 8.5 +/− 2.7 | 12.8 +/− 2.3 | 11.7 +/− 1.9 |
PTB/xHAM | 19.9 +/− 0.9 | 8.5 +/− 1.6 | 10.0 +/− 3.5 | 12.0 +/− 1.6 | 12.1 +/− 1.3 |
PTB/vein | 19.2 +/− 0.7 | 8.7 +/− 1.9 | 11.2 +/− 1.8 | 12.7 +/− 2.1 | 12.9 +/− 2/3 |
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Rossi, N.; Bejar-Chapa, M.; Giorgino, R.; Scott, B.B.; Kostyra, D.M.; Peretti, G.M.; Randolph, M.A.; Redmond, R.W. Photosealed Neurorrhaphy Using Autologous Tissue. Int. J. Mol. Sci. 2024, 25, 6958. https://doi.org/10.3390/ijms25136958
Rossi N, Bejar-Chapa M, Giorgino R, Scott BB, Kostyra DM, Peretti GM, Randolph MA, Redmond RW. Photosealed Neurorrhaphy Using Autologous Tissue. International Journal of Molecular Sciences. 2024; 25(13):6958. https://doi.org/10.3390/ijms25136958
Chicago/Turabian StyleRossi, Nicolò, Maria Bejar-Chapa, Riccardo Giorgino, Benjamin B. Scott, David M. Kostyra, Giuseppe M. Peretti, Mark A. Randolph, and Robert W. Redmond. 2024. "Photosealed Neurorrhaphy Using Autologous Tissue" International Journal of Molecular Sciences 25, no. 13: 6958. https://doi.org/10.3390/ijms25136958