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Volume 25
Issue 13
10.3390/ijms25136971
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Review
Peer-Review Record

The Postbiotic Properties of Butyrate in the Modulation of the Gut Microbiota: The Potential of Its Combination with Polyphenols and Dietary Fibers

Int. J. Mol. Sci. 2024, 25(13), 6971; https://doi.org/10.3390/ijms25136971
by Jessica Maiuolo 1,*,†, Rosa Maria Bulotta 1,†, Stefano Ruga 1, Saverio Nucera 1, Roberta Macrì 1, Federica Scarano 1, Francesca Oppedisano 1, Cristina Carresi 1, Micaela Gliozzi 1, Vincenzo Musolino 1, Rocco Mollace 2, Carolina Muscoli 1 and Vincenzo Mollace 1,2
Reviewer 1: Anonymous
Int. J. Mol. Sci. 2024, 25(13), 6971; https://doi.org/10.3390/ijms25136971
Submission received: 28 May 2024 / Revised: 15 June 2024 / Accepted: 19 June 2024 / Published: 26 June 2024
(This article belongs to the Special Issue Nutrition as a Tool for Modulating Cellular Metabolism)

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

The paper is well written and interesting. You could include a paragraph on strategies to deliver and increase butyrate levels and butyrate producing bacteria.

Author Response

Dear reviewer,
thanks for your advice. I send you attached my responses to your comments, which appear (even in the manscript) highlighted in blue.

Regards,

Jessica

Author Response File: Author Response.pdf

Reviewer 2 Report

Comments and Suggestions for Authors

1. In Figure 1, consider omitting the numbers one and two. You may begin with number three, indicating that the gut microbiota ferments fiber and carbohydrates into SCFAs. In the figure caption, provide a detailed description of each numbered process depicted in the figure.

2. In line 115, the phrase “acetate increases systemic concentrations in the blood” is vague. Please specify the substances whose concentrations are increased by acetate.

3. In Figure 2, all cells appear similar, but some are labeled as “colonocyte.” Are all the cells depicted intended to be colonocytes? According to the text, butyrate functions in various tissues and cells. Please clarify this distinction within the figure.

4. In Figure 3, include the effects of phenols, polyphenols, and fiber on the gut microbiota, supported by relevant literature. Ensure that this information is also reflected in the figure caption.

5. Before the conclusion section, it is necessary to outline directions for future research that address the points raised in the conclusions. Specify the types of studies required to investigate the primary questions regarding the role and effects of butyrate as a potential postbiotic.

6. In the conclusions section, avoid listing the relevant points numerically. Rephrase the conclusions to present the same information in a more fluid and integrated prose style.

Author Response

Dear reviewer,
thanks for your advice. I send you attached my responses to your comments, which appear (even in the manscript) highlighted in green.

Regards,

Jessica

Author Response File: Author Response.pdf

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