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Volume 25
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10.3390/ijms25147923
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Bicalutamide Enhances Conventional Chemotherapy in In Vitro and In Vivo Assays Using Human and Canine Inflammatory Mammary Cancer Cell Lines

by
Belen Crespo
1,
Juan Carlos Illera
1,
Gema Silvan
1,*,
Paula Lopez-Plaza
1,
María Herrera de la Muela
2,
Miriam de la Puente Yague
3,
Cristina Diaz del Arco
4,
Paloma Jimena de Andrés
5,
Maria Jose Illera
1 and
Sara Caceres
1
1
Department Animal Physiology, Veterinary Medicine School, Complutense University of Madrid (UCM), 28040 Madrid, Spain
2
Obstetrics and Gynecology Department, Hospital Clinico San Carlos, Instituto de Salud de la Mujer, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IsISSC), 28040 Madrid, Spain
3
Department of Public and Maternal Child Health University, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain
4
Department of Surgical Pathology, Hospital Clínico San Carlos, 28040 Madrid, Spain
5
Department of Animal Medicine, Surgery and Pathology, Veterinary Medicine School, Complutense University of Madrid, 28040 Madrid, Spain
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(14), 7923; https://doi.org/10.3390/ijms25147923
Submission received: 6 June 2024 / Revised: 9 July 2024 / Accepted: 16 July 2024 / Published: 19 July 2024
(This article belongs to the Special Issue Molecular Mechanisms and New Therapies for Breast Cancer)
Versions Notes

Abstract

Human inflammatory breast cancer (IBC) and canine inflammatory mammary cancer (IMC) are highly aggressive neoplastic diseases that share numerous characteristics. In IBC and IMC, chemotherapy produces a limited pathological response and anti-androgen therapies have been of interest for breast cancer treatment. Therefore, the aim was to evaluate the effect of a therapy based on bicalutamide, a non-steroidal anti-androgen, with doxorubicin and docetaxel chemotherapy on cell proliferation, migration, tumor growth, and steroid-hormone secretion. An IMC-TN cell line, IPC-366, and an IBC-TN cell line, SUM149, were used. In vitro assays revealed that SUM149 exhibited greater sensitivity, reducing cell viability and migration with all tested drugs. In contrast, IPC-366 exhibited only significant in vitro reductions with docetaxel as a single agent or in different combinations. Decreased estrogen levels reduced in vitro tumor growth in both IMC and IBC. Curiously, doxorubicin resulted in low efficacy, especially in IMC. In addition, all drugs reduced the tumor volume in IBC and IMC by increasing intratumoral testosterone (T) levels, which have been related with reduced tumor progression. In conclusion, the addition of bicalutamide to doxorubicin and docetaxel combinations may represent a potential treatment for IMC and IBC.
Keywords: doxorubicin; docetaxel; bicalutamide; inflammatory mammary cancer; inflammatory breast cancer; steroid hormones; androgen receptor doxorubicin; docetaxel; bicalutamide; inflammatory mammary cancer; inflammatory breast cancer; steroid hormones; androgen receptor

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MDPI and ACS Style

Crespo, B.; Illera, J.C.; Silvan, G.; Lopez-Plaza, P.; Herrera de la Muela, M.; de la Puente Yague, M.; Diaz del Arco, C.; de Andrés, P.J.; Illera, M.J.; Caceres, S. Bicalutamide Enhances Conventional Chemotherapy in In Vitro and In Vivo Assays Using Human and Canine Inflammatory Mammary Cancer Cell Lines. Int. J. Mol. Sci. 2024, 25, 7923. https://doi.org/10.3390/ijms25147923

AMA Style

Crespo B, Illera JC, Silvan G, Lopez-Plaza P, Herrera de la Muela M, de la Puente Yague M, Diaz del Arco C, de Andrés PJ, Illera MJ, Caceres S. Bicalutamide Enhances Conventional Chemotherapy in In Vitro and In Vivo Assays Using Human and Canine Inflammatory Mammary Cancer Cell Lines. International Journal of Molecular Sciences. 2024; 25(14):7923. https://doi.org/10.3390/ijms25147923

Chicago/Turabian Style

Crespo, Belen, Juan Carlos Illera, Gema Silvan, Paula Lopez-Plaza, María Herrera de la Muela, Miriam de la Puente Yague, Cristina Diaz del Arco, Paloma Jimena de Andrés, Maria Jose Illera, and Sara Caceres. 2024. "Bicalutamide Enhances Conventional Chemotherapy in In Vitro and In Vivo Assays Using Human and Canine Inflammatory Mammary Cancer Cell Lines" International Journal of Molecular Sciences 25, no. 14: 7923. https://doi.org/10.3390/ijms25147923

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