This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Open AccessArticle
Hypotensive and Cardioprotective Potential of Yellow Bedstraw Extract-Based Oral Liquid in Spontaneously Hypertensive Rats
by
Jovana Bradic
Jovana Bradic 1,2,
Anica Petrovic
Anica Petrovic 1,2,*,
Aleksandar Kocovic
Aleksandar Kocovic 1,2,
Slobodanka Mitrovic
Slobodanka Mitrovic 3,
Vladimir Jakovljevic
Vladimir Jakovljevic 2,4,5,
Nevena Lazarevic
Nevena Lazarevic 1,2,
Sergey Bolevich
Sergey Bolevich 5 and
Igor Simanic
Igor Simanic 6,7
1
Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozara Markovica St., 34000 Kragujevac, Serbia
2
Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders, 69 Svetozara Markovica St., 34000 Kragujevac, Serbia
3
Department of Pathology, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozara Markovica St., 34000 Kragujevac, Serbia
4
Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozara Markovica St., 34000 Kragujevac, Serbia
5
Department of Human Pathology, Sechenov First Moscow State Medical University, 8 Trubetskaya Street St., 119991 Moscow, Russia
6
Specialized Hospital for Rehabilitation and Orthopedic Prosthetics, Sokobanjska 17, 11000 Beograd, Serbia
7
Department of Physical Medicine and Rehabilitation, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozara Markovica St., 34000 Kragujevac, Serbia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(15), 8346; https://doi.org/10.3390/ijms25158346 (registering DOI)
Submission received: 26 June 2024
/
Revised: 23 July 2024
/
Accepted: 28 July 2024
/
Published: 30 July 2024
Abstract
This study aimed to prepare, characterize and assess the antioxidant activity of yellow bedstraw extracts (YBEs), focusing on identifying extracts with high antioxidant capacity. The selected extract was loaded into an oral liquid formulation and further investigated for its therapeutic potential in reducing blood pressure and associated complications in spontaneously hypertensive Wistar kyoto rats (SHR). Rats were divided into untreated SHR and SHR treated with a YBE-based oral formulation over four weeks. After treatment, blood pressure was measured, and cardiac function was assessed using the Langendorff technique to simulate ex vivo ischemic conditions. Prooxidant levels were assessed in plasma while antioxidant activity was evaluated in red blood cells. Histological analyses of heart, kidney, and liver samples were conducted to assess pathological changes induced by hypertension. Our results showed that the oral formulation loaded with ethanol YBE effectively reduced blood pressure, preserved myocardial function under ischemic stress, and decreased oxidative stress markers in blood. Importantly, our formulation with YBE demonstrated potential in attenuating structural kidney damage associated with hypertension. Overall, these findings suggest a cardioprotective effect of orally administered YBE formulation, highlighting its potential as an herbal supplement. However, clinical studies are warranted to validate these findings and explore the extract’s suitability for clinical use.
Share and Cite
MDPI and ACS Style
Bradic, J.; Petrovic, A.; Kocovic, A.; Mitrovic, S.; Jakovljevic, V.; Lazarevic, N.; Bolevich, S.; Simanic, I.
Hypotensive and Cardioprotective Potential of Yellow Bedstraw Extract-Based Oral Liquid in Spontaneously Hypertensive Rats. Int. J. Mol. Sci. 2024, 25, 8346.
https://doi.org/10.3390/ijms25158346
AMA Style
Bradic J, Petrovic A, Kocovic A, Mitrovic S, Jakovljevic V, Lazarevic N, Bolevich S, Simanic I.
Hypotensive and Cardioprotective Potential of Yellow Bedstraw Extract-Based Oral Liquid in Spontaneously Hypertensive Rats. International Journal of Molecular Sciences. 2024; 25(15):8346.
https://doi.org/10.3390/ijms25158346
Chicago/Turabian Style
Bradic, Jovana, Anica Petrovic, Aleksandar Kocovic, Slobodanka Mitrovic, Vladimir Jakovljevic, Nevena Lazarevic, Sergey Bolevich, and Igor Simanic.
2024. "Hypotensive and Cardioprotective Potential of Yellow Bedstraw Extract-Based Oral Liquid in Spontaneously Hypertensive Rats" International Journal of Molecular Sciences 25, no. 15: 8346.
https://doi.org/10.3390/ijms25158346
Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details
here.
Article Metrics
Article Access Statistics
For more information on the journal statistics, click
here.
Multiple requests from the same IP address are counted as one view.