Pro-Osteogenic Effect of the Nutraceutical BlastiMin Complex® in Women with Osteoporosis or Osteopenia: An Open Intervention Clinical Trial
Abstract
:1. Introduction
2. Results
2.1. Effects of BlastiMin Complex® on Serum BTMs, CRP, and BMD Values
2.2. Analysis of Selected SNPs of COL1A1, RANKL, RANK, VDR, and CTR Genes
3. Discussion
4. Materials and Methods
4.1. Study Design
4.2. Treatment
4.3. Assessments
4.4. Polymerase Chain Reaction for the SNP Analysis
4.5. BMD Measurement
4.6. Statistical Analysis
5. Conclusions
6. Patents
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Parameters | t0 months | t6 months | t12 months |
---|---|---|---|
Vitamin D2 + D3 (ng/mL) | 33.62 ± 12.87 | 33.91 ± 9.47 | 32.60 ± 8.31 |
P1NP (μg/L) | 63.64 ± 17.80 | 71.43 ± 26.49 * | 74.30 ± 24.57 *** |
CTX (pg/mL) | 381.67 ± 152.14 | 430.88 ± 130.18 * | 406.60 ± 160.42 |
OCN (ng/mL) | 21.59 ± 5.46 | 20.35 ± 4.20 | 22.41 ± 5.92 |
bALP (ng/mL) | 14.56 ± 6.44 | 14.72 ± 4.61 | 15.03 ± 6.02 |
CRP (mg/dL) | 0.26 ± 0.05 | 0.22 ± 0.07 | 0.12 ± 0.09 *** |
BTI | 0.167 | 0.166 | 0.183 |
BMD L1-L4 (g/cm2) | 0.831 ± 0.08 | 0.834 ± 0.07 | 0.829 ± 0.08 |
BMD FN (g/cm2) | 0.640 ± 0.08 | 0.640 ± 0.07 | 0.627 ± 0.08 |
Parameters | t0 months | t12 months |
---|---|---|
DXA L1-L4 T-score | −1.512 ± 1.029 | −1.551 ± 1.014 |
DXA FN T-score | −1.514 ± 0.607 | −1.515 ± 0.687 |
REMS L1-L4 T-score | −1.96 ± 0.68 | −2.00 ± 0.71 |
REMS FN T-score | −1.88 ± 0.74 | −1.98 ± 0.74 |
Gene | SNP | Homozygous wt | Heterozygous | Homozygous Mut |
---|---|---|---|---|
CTR | rs1801197 T>C | 56.8% | 40.9% | 2.3% |
VDR | rs17879735 G>T | 29.6% | 45.4% | 25.0% |
VDR | rs1544410 G>A | 43.2% | 43.2% | 13.6% |
VDR | rs11568820 G>A | 50.0% | 43.2% | 6.8% |
VDR | rs2228570 T>C | 50.0% | 40.9% | 9.1% |
VDR | rs731236 T>C | 59.1% | 47.7% | 11.4% |
COL1A1 | rs1800012 G>T | 68.2% | 27.3% | 4.5% |
RANK | rs3018362 A>G | 65.9% | 59.1% | 6.8% |
RANKL | rs9594759 C>T | 18.2% | 54.5% | 27.3% |
RANKL | rs9594738 C>T | 22.7% | 59.1% | 18.2% |
Characteristics | |
---|---|
Sex, no. (%) | |
Male | 0% |
Female | 100% |
Age, y | 62.4 ± 6.1 |
Weight, kg | 63.5 ± 9.8 |
BMI | 24.1 ± 3.5 |
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Sabatelli, S.; Scarpa, E.-S.; Giuliani, A.; Giordani, C.; Sabbatinelli, J.; Rippo, M.R.; Cabodi, S.; Petrini, B.; Balercia, G.; Giacchetti, G. Pro-Osteogenic Effect of the Nutraceutical BlastiMin Complex® in Women with Osteoporosis or Osteopenia: An Open Intervention Clinical Trial. Int. J. Mol. Sci. 2024, 25, 8565. https://doi.org/10.3390/ijms25168565
Sabatelli S, Scarpa E-S, Giuliani A, Giordani C, Sabbatinelli J, Rippo MR, Cabodi S, Petrini B, Balercia G, Giacchetti G. Pro-Osteogenic Effect of the Nutraceutical BlastiMin Complex® in Women with Osteoporosis or Osteopenia: An Open Intervention Clinical Trial. International Journal of Molecular Sciences. 2024; 25(16):8565. https://doi.org/10.3390/ijms25168565
Chicago/Turabian StyleSabatelli, Sofia, Emanuele-Salvatore Scarpa, Angelica Giuliani, Chiara Giordani, Jacopo Sabbatinelli, Maria Rita Rippo, Sara Cabodi, Barbara Petrini, Giancarlo Balercia, and Gilberta Giacchetti. 2024. "Pro-Osteogenic Effect of the Nutraceutical BlastiMin Complex® in Women with Osteoporosis or Osteopenia: An Open Intervention Clinical Trial" International Journal of Molecular Sciences 25, no. 16: 8565. https://doi.org/10.3390/ijms25168565