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Department of Orthopaedic Surgery and Rehabilitation, University of Texas Medical Branch, Galveston, TX 77555-0165, USA
Department of Health Sciences, University “Magna Graecia” of Catanzaro, 88100 Catanzaro, Italy
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Bone as an Endocrine Organ

Abstract submission deadline
closed (31 August 2024)
Manuscript submission deadline
31 October 2024
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Topic Information

Dear Colleagues,

Increasing evidence shows that bone is very much an interactive organ in the body and plays an integral role in the functioning or malfunctioning of other organs and tissues. Often, it does this by releasing substances that affect metabolism in ways we could not previously imagine. Some examples of this include the roles of osteocalcin in glucose metabolism and skeletal muscle function and Transforming Growth Factor-Beta in muscle protein degradation. Yet, many questions are unanswered. For example, bone contains and releases substances that are anabolic and catabolic to other tissues. What signals bone to release them and in what quantities? What are the metabolic fates of released calcium, phosphate and magnesium in health and disease? How do these releases affect other organs in different disease states?

Prof. Dr. Gordon L. Klein
Prof. Dr. Antonio Brunetti
Topic Editors

Keywords

  • bone
  • osteocalcin
  • transforming growth factor -beta
  • oxidative stress
  • interleukin-6
  • skeletal muscle
  • heart
  • angiotensin II
  • smad signaling

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Cells
cells 		5.1 9.9 2012 17.5 Days CHF 2700 Submit
Endocrines
endocrines 		- - 2020 38.7 Days CHF 1000 Submit
International Journal of Molecular Sciences
ijms 		4.9 8.1 2000 18.1 Days CHF 2900 Submit
Journal of Clinical Medicine
jcm 		3.0 5.7 2012 17.3 Days CHF 2600 Submit
Metabolites
metabolites 		3.4 5.7 2011 13.9 Days CHF 2700 Submit

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Published Papers (2 papers)

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13 pages, 584 KiB  
Article
Pro-Osteogenic Effect of the Nutraceutical BlastiMin Complex® in Women with Osteoporosis or Osteopenia: An Open Intervention Clinical Trial
by Sofia Sabatelli, Emanuele-Salvatore Scarpa, Angelica Giuliani, Chiara Giordani, Jacopo Sabbatinelli, Maria Rita Rippo, Sara Cabodi, Barbara Petrini, Giancarlo Balercia and Gilberta Giacchetti
Int. J. Mol. Sci. 2024, 25(16), 8565; https://doi.org/10.3390/ijms25168565 - 6 Aug 2024
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Abstract
Osteoporosis is a chronic disease that affects millions of patients worldwide and is characterized by low bone mineral density (BMD) and increased risk of fractures. Notably, natural molecules can increase BMD and exert pro-osteogenic effects. Noteworthily, the nutraceutical BlastiMin Complex® (Mivell, Italy, [...] Read more.
Osteoporosis is a chronic disease that affects millions of patients worldwide and is characterized by low bone mineral density (BMD) and increased risk of fractures. Notably, natural molecules can increase BMD and exert pro-osteogenic effects. Noteworthily, the nutraceutical BlastiMin Complex® (Mivell, Italy, European Patent Application EP4205733A1) can induce differentiation of human bone marrow mesenchymal stem cells (BM-MSCs) in osteoblasts and can exert in vitro pro-osteogenic and anti-inflammatory effects. Thus, the purpose of this study was to verify the effects of BlastiMin Complex® on bone turnover markers (BTMs) and BMD in patients with senile and postmenopausal osteopenia or osteoporosis. The efficacy of BlastiMin Complex® on BTMs in serum was evaluated through biochemical assays. BMD values were analyzed by dual-energy X-ray absorptiometry (DXA) and Radiofrequency Echographic Multi Spectrometry (R.E.M.S.) techniques, and the SNPs with a role in osteoporosis development were evaluated by PCR. Clinical data obtained after 12 months of treatment showed an increase in bone turnover index, a decrease in C-reactive protein levels, and a remarkable increase in P1NP levels, indicating the induction of osteoblast proliferation and activity in the cohort of 100% female patients recruited for the study. These findings show that the nutraceutical BlastiMin Complex® could be used as an adjuvant in combination with synthetic drugs for the treatment of osteoporosis pathology. Full article
(This article belongs to the Topic Bone as an Endocrine Organ)
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10 pages, 1874 KiB  
Communication
Vibration Rather than Microgravity Affects Bone Metabolism in Adult Zebrafish Scale Model
by Marta Carnovali, Stefania Zava, Giuseppe Banfi, Angela Maria Rizzo and Massimo Mariotti
Cells 2024, 13(6), 509; https://doi.org/10.3390/cells13060509 - 14 Mar 2024
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Abstract
Gravity and mechanical forces cause important alterations in the human skeletal system, as demonstrated by space flights. Innovative animal models like zebrafish embryos and medaka have been introduced to study bone response in ground-based microgravity simulators. We used, for the first time, adult [...] Read more.
Gravity and mechanical forces cause important alterations in the human skeletal system, as demonstrated by space flights. Innovative animal models like zebrafish embryos and medaka have been introduced to study bone response in ground-based microgravity simulators. We used, for the first time, adult zebrafish in simulated microgravity, with a random positioning machine (RPM) to study bone remodeling in the scales. To evaluate the effects of microgravity on bone remodeling in adult bone tissue, we exposed adult zebrafish to microgravity for 14 days using RPM and we evaluated bone remodeling on explanted scales. Our data highlight bone resorption in scales in simulated microgravity fish but also in the fish exposed, in normal gravity, to the vibrations produced by the RPM. The osteoclast activation in both rotating and non-rotating samples suggest that prolonged vibrations exposure leads to bone resorption in the scales tissue. Stress levels in these fish were normal, as demonstrated by blood cortisol quantification. In conclusion, vibrational mechanical stress induced bone resorption in adult fish scales. Moreover, adult fish as an animal model for microgravity studies remains controversial since fish usually live in weightless conditions because of the buoyant force from water and do not constantly need to support their bodies against gravity. Full article
(This article belongs to the Topic Bone as an Endocrine Organ)
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