Role of PRMT1 and PRMT5 in Breast Cancer
Round 1
Reviewer 1 Report
Comments and Suggestions for AuthorsPlease see the attached.
Comments for author File: Comments.pdf
Author Response
Please see the attachment
Author Response File: Author Response.pdf
Reviewer 2 Report
Comments and Suggestions for AuthorsThe authors conduct a comprehensive review of current literature delineating the role of Protein Arginine Methyltransferases 1 and 5 (PRMT 1&5) in breast cancer. They summarize the findings from research conducted by their group and others, categorize the effects and targets of PRMT1 and 5-mediated methylation in breast cancer, and review the current state of PRMT1/5 targeted therapy.
The review flows well, includes informative graphical summaries and discusses recent developments.
Major comments:
1. Since the review specifically discusses breast cancer, it would be useful to include Kaplan Meier curves for association of PRMT1 and 5 with prognosis in different subtypes of breast cancer (PFS, OS).
2. The manuscript would be strengthened by including a summary table outlining the PRMT1/5 inhibitors discussed in sections 5.1 and 5.2 categorized by MOA, stages of development i.e preclinical/clinical trials, intended use as monotherapy or combination with chemo/radiation/surgery/immunotherapy etc.
3. The manuscript would be further strengthened by also summarizing emerging literature on other roles of PRMT1/5 in breast cancer including alternative splicing, effect on immunotherapy efficacy, chemoresistance etc.
Minor comments:
1. Correct the spelling to “inhibits” in Table 1
Comments on the Quality of English LanguageMinor comment:
1. Correct the spelling to “inhibits” in Table 1
Author Response
Please see the attachment
Author Response File: Author Response.pdf