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Volume 25
Issue 16
10.3390/ijms25168943
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Different Prostatic Tissue Microbiomes between High- and Low-Grade Prostate Cancer Pathogenesis

by
Jae Heon Kim
1,2,†,
Hoonhee Seo
3,†,
Sukyung Kim
3,
Md Abdur Rahim
2,3,
Sujin Jo
2,3,
Indrajeet Barman
2,3,
Hanieh Tajdozian
2,3,
Faezeh Sarafraz
2,3,
Ho-Yeon Song
2,3,* and
Yun Seob Song
1,*
1
Department of Urology, Soonchunhyang University School of Medicine, Seoul 04401, Republic of Korea
2
Department of Microbiology and Immunology, School of Medicine, Soonchunhyang University, Asan 31151, Republic of Korea
3
Human Microbiome Medical Research Center (HM-MRC), Soonchunhyang University, Asan 31538, Republic of Korea
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2024, 25(16), 8943; https://doi.org/10.3390/ijms25168943
Submission received: 28 June 2024 / Revised: 10 August 2024 / Accepted: 14 August 2024 / Published: 16 August 2024
(This article belongs to the Special Issue Cutting Edge Advances in Prostate Cancer)
Versions Notes

Abstract

Numerous human pathologies, such as neoplasia, are related to particular bacteria and changes in microbiome constituents. To investigate the association between an imbalance of bacteria and prostate carcinoma, the microbiome and gene functionality from tissues of patients with high-grade prostate tumor (HGT) and low-grade prostate tumor (LGT) were compared utilizing next-generation sequencing (NGS) technology. The results showed abnormalities in the bacterial profiles between the HGT and LGT specimens, indicating alterations in the make-up of bacterial populations and gene functionalities. The HGT specimens showed higher frequencies of Cutibacterium, Pelomonas, and Corynebacterium genera than the LGT specimens. Cell proliferation and cytokine assays also showed a significant proliferation of prostate cancer cells and elevated cytokine levels in the cells treated with Cutibacterium, respectively, supporting earlier findings. In summary, the HGT and LGT specimens showed differences in bacterial populations, suggesting that different bacterial populations might characterize high-grade and low-grade prostate malignancies.
Keywords: prostate cancer; high-grade prostate tumor (HGT); low-grade prostate tumor (LGT); biomarker; Cutibacterium; therapeutic targets prostate cancer; high-grade prostate tumor (HGT); low-grade prostate tumor (LGT); biomarker; Cutibacterium; therapeutic targets

Share and Cite

MDPI and ACS Style

Kim, J.H.; Seo, H.; Kim, S.; Rahim, M.A.; Jo, S.; Barman, I.; Tajdozian, H.; Sarafraz, F.; Song, H.-Y.; Song, Y.S. Different Prostatic Tissue Microbiomes between High- and Low-Grade Prostate Cancer Pathogenesis. Int. J. Mol. Sci. 2024, 25, 8943. https://doi.org/10.3390/ijms25168943

AMA Style

Kim JH, Seo H, Kim S, Rahim MA, Jo S, Barman I, Tajdozian H, Sarafraz F, Song H-Y, Song YS. Different Prostatic Tissue Microbiomes between High- and Low-Grade Prostate Cancer Pathogenesis. International Journal of Molecular Sciences. 2024; 25(16):8943. https://doi.org/10.3390/ijms25168943

Chicago/Turabian Style

Kim, Jae Heon, Hoonhee Seo, Sukyung Kim, Md Abdur Rahim, Sujin Jo, Indrajeet Barman, Hanieh Tajdozian, Faezeh Sarafraz, Ho-Yeon Song, and Yun Seob Song. 2024. "Different Prostatic Tissue Microbiomes between High- and Low-Grade Prostate Cancer Pathogenesis" International Journal of Molecular Sciences 25, no. 16: 8943. https://doi.org/10.3390/ijms25168943

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