Abstract
Numerous human pathologies, such as neoplasia, are related to particular bacteria and changes in microbiome constituents. To investigate the association between an imbalance of bacteria and prostate carcinoma, the microbiome and gene functionality from tissues of patients with high-grade prostate tumor (HGT) and low-grade prostate tumor (LGT) were compared utilizing next-generation sequencing (NGS) technology. The results showed abnormalities in the bacterial profiles between the HGT and LGT specimens, indicating alterations in the make-up of bacterial populations and gene functionalities. The HGT specimens showed higher frequencies of Cutibacterium, Pelomonas, and Corynebacterium genera than the LGT specimens. Cell proliferation and cytokine assays also showed a significant proliferation of prostate cancer cells and elevated cytokine levels in the cells treated with Cutibacterium, respectively, supporting earlier findings. In summary, the HGT and LGT specimens showed differences in bacterial populations, suggesting that different bacterial populations might characterize high-grade and low-grade prostate malignancies.
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MDPI and ACS Style
Kim, J.H.; Seo, H.; Kim, S.; Rahim, M.A.; Jo, S.; Barman, I.; Tajdozian, H.; Sarafraz, F.; Song, H.-Y.; Song, Y.S.
Different Prostatic Tissue Microbiomes between High- and Low-Grade Prostate Cancer Pathogenesis. Int. J. Mol. Sci. 2024, 25, 8943.
https://doi.org/10.3390/ijms25168943
AMA Style
Kim JH, Seo H, Kim S, Rahim MA, Jo S, Barman I, Tajdozian H, Sarafraz F, Song H-Y, Song YS.
Different Prostatic Tissue Microbiomes between High- and Low-Grade Prostate Cancer Pathogenesis. International Journal of Molecular Sciences. 2024; 25(16):8943.
https://doi.org/10.3390/ijms25168943
Chicago/Turabian Style
Kim, Jae Heon, Hoonhee Seo, Sukyung Kim, Md Abdur Rahim, Sujin Jo, Indrajeet Barman, Hanieh Tajdozian, Faezeh Sarafraz, Ho-Yeon Song, and Yun Seob Song.
2024. "Different Prostatic Tissue Microbiomes between High- and Low-Grade Prostate Cancer Pathogenesis" International Journal of Molecular Sciences 25, no. 16: 8943.
https://doi.org/10.3390/ijms25168943
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