The Roles of Obesity and ASB4 in Preeclampsia Pathogenesis
Abstract
:1. Introduction
2. Preeclampsia
3. Obesity and Preeclampsia
3.1. Insulin
3.1.1. Insulin and Implantation
3.1.2. Excess Insulin in Maternal Endometrial Receptivity
3.1.3. Excess Insulin in Trophoblast Cells
3.1.4. Insulin in Maternal Endothelium
3.2. Leptin
3.2.1. Leptin and Implantation
3.2.2. Excess Leptin in Maternal Endometrial Receptivity
3.2.3. Excess Leptin in Trophoblast Cells
3.2.4. Leptin in Maternal Endothelium
4. ASB4
4.1. ASB4 and Obesity
4.2. ASB4 and Vascular Development
4.3. ASB4 and Preeclampsia
4.3.1. ASB4, Implantation, and Preeclampsia
4.3.2. ASB4, Obesity, and Preeclampsia
5. Conclusions
6. Future Directions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Visceral Adipose Tissue (g) | P-Cholesterol (mg/dL) | P-Triglyceride (mg/dL) | P-Glucose (mg/dL) | P-Insulin (mg/dL) | P-Leptin (mg/dL) | Fetal Number (#) | Fetal Weight (g) | Placental Weight (g) | |
---|---|---|---|---|---|---|---|---|---|
NC-WT | - | - | - | - | - | - | - | - | - |
HFD-WT | - | - | - | - | - | ↑ [74] | - | - | - |
NC-Asb4−/− | - | - | - | - | - | - | ↓ | - | ↑ |
HFD-Asb4−/− | ↑ | ↑ | - | - | ↑ | ↑↑ | ↓↓ | - | ↑ |
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Wang, Y.; Ssengonzi, R.; Townley-Tilson, W.H.D.; Kayashima, Y.; Maeda-Smithies, N.; Li, F. The Roles of Obesity and ASB4 in Preeclampsia Pathogenesis. Int. J. Mol. Sci. 2024, 25, 9017. https://doi.org/10.3390/ijms25169017
Wang Y, Ssengonzi R, Townley-Tilson WHD, Kayashima Y, Maeda-Smithies N, Li F. The Roles of Obesity and ASB4 in Preeclampsia Pathogenesis. International Journal of Molecular Sciences. 2024; 25(16):9017. https://doi.org/10.3390/ijms25169017
Chicago/Turabian StyleWang, Yuye, Rebecca Ssengonzi, W. H. Davin Townley-Tilson, Yukako Kayashima, Nobuyo Maeda-Smithies, and Feng Li. 2024. "The Roles of Obesity and ASB4 in Preeclampsia Pathogenesis" International Journal of Molecular Sciences 25, no. 16: 9017. https://doi.org/10.3390/ijms25169017