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Cellular and Molecular Targets of Preeclampsia

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Guest Editor
Department of Obstetrics and Gynecology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan
Interests: microRNA; fetal abnormality; placenta accreta spectrum; postpartum hemorrhage; trophoblast invasion
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Special Issue Information

Dear Colleagues,

Preeclampsia remains one of the most important diseases in perinatology. Although the cause of the disease has long been unknown, tireless efforts carried out by researchers have made a steady progress in relation to etiology and prevention. Of those, the use of low-dose aspirin (used for the prevention of preterm preeclampsia) represents a milestone. However, numerous aspects of preeclampsia remain unknown, necessitating further research. In this Special Issue, we invite a wide range of contributions associated with preeclampsia, with a primary focus on the molecular level and basic research. We also welcome translational research. We hope that this project will serve as a valuable contribution to the advances within the field of preeclampsia.

Prof. Dr. Hironori Takahashi
Guest Editor

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Keywords

  • biomarker
  • cell biology
  • remodeling
  • human placenta
  • trophoblast
  • exosome
  • invasion
  • preeclampsia
  • fetal growth restriction

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Published Papers (1 paper)

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Review

13 pages, 845 KiB  
Review
The Roles of Obesity and ASB4 in Preeclampsia Pathogenesis
by Yuye Wang, Rebecca Ssengonzi, W. H. Davin Townley-Tilson, Yukako Kayashima, Nobuyo Maeda-Smithies and Feng Li
Int. J. Mol. Sci. 2024, 25(16), 9017; https://doi.org/10.3390/ijms25169017 - 20 Aug 2024
Viewed by 1477
Abstract
Preeclampsia is a complex pregnancy-related hypertensive disorder which poses significant risks for both maternal and fetal health. Preeclampsia affects 5–8% of pregnancies in the United States, causing a significant public health and economic burden. Despite extensive research, the etiology and pathogenesis of preeclampsia [...] Read more.
Preeclampsia is a complex pregnancy-related hypertensive disorder which poses significant risks for both maternal and fetal health. Preeclampsia affects 5–8% of pregnancies in the United States, causing a significant public health and economic burden. Despite extensive research, the etiology and pathogenesis of preeclampsia remain elusive, but have been correlated with maternal conditions such as obesity. In recent decades, the incidence of preeclampsia increased along with the prevalence of obesity among women of reproductive age. Maternal obesity has been shown to negatively affect pregnancy in almost all aspects. However, the precise mechanisms by which obesity influences preeclampsia are unclear. Ankyrin repeat and SOCS Box Containing protein 4 (ASB4) is an E3 ubiquitin ligase that can promote the degradation of a wide range of target proteins. ASB4-null mice display a full spectrum of preeclampsia-like phenotypes during pregnancy including hypertension, proteinuria, and decreased litter size. Furthermore, maternal obesity induced by a high-fat diet aggravates preeclampsia-like phenotypes in pregnant mice lacking ASB4. Variants in the ASB4 gene have been associated with obesity in humans, and a functional connection between the ASB4 gene and obesity has been established in mice. This review discusses the connections between preeclampsia, obesity, and ASB4. Full article
(This article belongs to the Special Issue Cellular and Molecular Targets of Preeclampsia)
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