Influence of Exercise and Genistein to Mitigate the Deleterious Effects of High-Fat High-Sugar Diet on Alzheimer’s Disease-Related Markers in Male Mice
Abstract
:1. Introduction
2. Results
2.1. Physical Characteristics
2.2. Evaluation of Key Proteins Involved in Alzheimer’s Disease
2.3. Behavioral Assessments
3. Discussion
4. Materials and Methods
4.1. Mouse Model of Diet Induced Diabetic Obesity
4.2. Behavioral Assessments
4.3. Western Blot Analysis for Total Protein Expression
4.4. Serum Measures
4.5. Statistics
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
TNF-α | Tumor necrosis factor-alpha |
Aβ | Amyloid beta |
pGSK-3β | Phosphorylated glycogen synthase kinase |
GSK-3β | Glycogen synthase kinase |
APP | Amyloid precursor protein |
NFT | Neurofibrillary tangles |
BDNF | Brain-derived neurotrophic factor |
NGF | Nerve growth factor |
HFHS | High-fat high-sugar |
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Shah, J.; Orosz, T.; Singh, A.; Laxma, S.P.; Gross, R.E.; Smith, N.; Vroegop, S.; Sudler, S.; Porter, J.T.; Colon, M.; et al. Influence of Exercise and Genistein to Mitigate the Deleterious Effects of High-Fat High-Sugar Diet on Alzheimer’s Disease-Related Markers in Male Mice. Int. J. Mol. Sci. 2024, 25, 9019. https://doi.org/10.3390/ijms25169019
Shah J, Orosz T, Singh A, Laxma SP, Gross RE, Smith N, Vroegop S, Sudler S, Porter JT, Colon M, et al. Influence of Exercise and Genistein to Mitigate the Deleterious Effects of High-Fat High-Sugar Diet on Alzheimer’s Disease-Related Markers in Male Mice. International Journal of Molecular Sciences. 2024; 25(16):9019. https://doi.org/10.3390/ijms25169019
Chicago/Turabian StyleShah, Juhi, Tyler Orosz, Avneet Singh, Savan Parameshwar Laxma, Rachel E. Gross, Nicholas Smith, Spencer Vroegop, Sydney Sudler, James T. Porter, Maria Colon, and et al. 2024. "Influence of Exercise and Genistein to Mitigate the Deleterious Effects of High-Fat High-Sugar Diet on Alzheimer’s Disease-Related Markers in Male Mice" International Journal of Molecular Sciences 25, no. 16: 9019. https://doi.org/10.3390/ijms25169019