This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Open AccessReview
Toxicological and Pharmacological Activities, and Potential Medical Applications, of Marine Algal Toxins
by
Xinyu Gao
Xinyu Gao 1,2,
Hanyi Wang
Hanyi Wang 1,3,
Kuilin Chen
Kuilin Chen 1,2,
Yifan Guo
Yifan Guo 1,3,
Jin Zhou
Jin Zhou 4,*
and
Weidong Xie
Weidong Xie 1,3,*
1
State Key Laboratory of Chemical Oncogenomics, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China
2
Shenzhen Key Laboratory of Health Science and Technology, Institute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China
3
Open FIESTA Center, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China
4
Institute for Ocean Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(17), 9194; https://doi.org/10.3390/ijms25179194 (registering DOI)
Submission received: 24 July 2024
/
Revised: 22 August 2024
/
Accepted: 23 August 2024
/
Published: 24 August 2024
Abstract
Marine algal toxins have garnered significant attention in the research community for their unique biochemical properties and potential medical applications. These bioactive compounds, produced by microalgae, pose significant risks due to their high toxicity, yet offer promising therapeutic benefits. Despite extensive research identifying over 300 marine algal toxins, including azaspiracids, brevetoxins, cyclic imines, and yessotoxins, gaps remain in the understanding of their pharmacological potential. In this paper, we critically review the classification, bioactive components, toxicology, pharmacological activities, and mechanisms of these toxins, with a particular focus on their clinical applications. Our motivation stems from the increasing interest in marine algal toxins as candidates for drug development, driven by their high specificity and affinity for various biological receptors. We aim to bridge the gap between toxicological research and therapeutic application, offering insights into the advantages and limitations of these compounds in comparison to other bioactive substances. This review not only enhances the understanding of marine algal toxins’ complexity and diversity, but also highlights their extensive application potential in medicine and bioscience, providing a foundation for future research and development in this field.
Share and Cite
MDPI and ACS Style
Gao, X.; Wang, H.; Chen, K.; Guo, Y.; Zhou, J.; Xie, W.
Toxicological and Pharmacological Activities, and Potential Medical Applications, of Marine Algal Toxins. Int. J. Mol. Sci. 2024, 25, 9194.
https://doi.org/10.3390/ijms25179194
AMA Style
Gao X, Wang H, Chen K, Guo Y, Zhou J, Xie W.
Toxicological and Pharmacological Activities, and Potential Medical Applications, of Marine Algal Toxins. International Journal of Molecular Sciences. 2024; 25(17):9194.
https://doi.org/10.3390/ijms25179194
Chicago/Turabian Style
Gao, Xinyu, Hanyi Wang, Kuilin Chen, Yifan Guo, Jin Zhou, and Weidong Xie.
2024. "Toxicological and Pharmacological Activities, and Potential Medical Applications, of Marine Algal Toxins" International Journal of Molecular Sciences 25, no. 17: 9194.
https://doi.org/10.3390/ijms25179194
Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details
here.
Article Metrics
Article Access Statistics
For more information on the journal statistics, click
here.
Multiple requests from the same IP address are counted as one view.