Molecular Sex Differences and Clinical Gender Efficacy in Opioid Use Disorders: From Pain Management to Addiction
Abstract
:1. Introduction
2. Discussion
2.1. Pain Modulation and Hormonal Influences
2.2. Addiction and Opioid Withdrawal
3. Materials and Methods
4. Conclusions and Future Directions
Author Contributions
Funding
Institutional Review Board Statement
Conflicts of Interest
References
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Articles | Research Subjects | Experimental Model | Results |
---|---|---|---|
Papaleo et al., 2006 [3] | C57BL/6J mouse | Spontaneous opiate withdrawal somatic signs —morphine | Sex- and dose-dependent (↑ female) |
Tisdale at al., 2024 [6] | C57BL/6J mouse | Spontaneous opioid withdrawal —morphine | Sex-dependent effects on sleep (↑ female) |
Sharp et al., 2021 [7] | Multiple rat strains | Self-administration protocol —oxycodone | Different self-administration behavior Strain-dependent |
Choo et al., 2014 [13] | Human | DAWN data collection | Gender differences among opioid users seeking emergency care |
Craft et al., 2001 [16] | Rat | Investigation of the antinociceptive effects of µ opioid agonists | Sex differences not related to µ opioid agonists, κ opioid antinociception may be primarily spinal rather than supraspinal |
Wang et al., 2006 [24] | Rat | Thermal hyperalgesia —morphine | Sex differences in the anti-hyperalgesic action of morphine |
Bobeck et al., 2009 [25] | Rat | Comparison of the antinociceptive actions of various opioids | GABAergic neuron inhibition produces greater antinociception in males |
Bai et al., 2015 [26] | Rat | Orofacial persistent pain model | Sex differences in the effects of peripheral MOR agonists in long-lasting pain condition |
Terner et al., 2006 [27] | Rat | Excitatory action of morphine —morphine and naltrexone | No sex or strain differences in opioid sensitivity with low doses of naltrexone |
Sarton et al., 2000 [29] | Human | Pain threshold and tolerance —morphine | Sex differences in morphine potency and onset–offset speed |
Barret et al., 2003 [30] | Rat | Capsaicin-induced hyperalgesia | Comparable effect of morphine |
Mohammadian et al., 2019 [38] | Rat | Chronic morphine administration | Sex differences in the duration of morphine withdrawal |
Iyer et al., 2022 [39] | C57BL/6J mouse | Voluntary consumption of oxycodone | No sex-dependent differences |
Santoro et al., 2017 [40] | Rat | Simulation of opioid abuse and opioid replacement | Sex-dependent changes in selected areas of the CNS |
Borrelli et al., 2021 [41] | Neonatal outbred mouse | Simulation of neonatal withdrawal syndrome | Sex-dependent differences, vocalization, transcriptional alterations |
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Concato, M.; Giacomello, E.; Al-Habash, I.; Alempijevic, D.; Kolev, Y.G.; Buffon, M.; Radaelli, D.; D’Errico, S. Molecular Sex Differences and Clinical Gender Efficacy in Opioid Use Disorders: From Pain Management to Addiction. Int. J. Mol. Sci. 2024, 25, 9314. https://doi.org/10.3390/ijms25179314
Concato M, Giacomello E, Al-Habash I, Alempijevic D, Kolev YG, Buffon M, Radaelli D, D’Errico S. Molecular Sex Differences and Clinical Gender Efficacy in Opioid Use Disorders: From Pain Management to Addiction. International Journal of Molecular Sciences. 2024; 25(17):9314. https://doi.org/10.3390/ijms25179314
Chicago/Turabian StyleConcato, Monica, Emiliana Giacomello, Ibrahim Al-Habash, Djordje Alempijevic, Yanko Georgiev Kolev, Maria Buffon, Davide Radaelli, and Stefano D’Errico. 2024. "Molecular Sex Differences and Clinical Gender Efficacy in Opioid Use Disorders: From Pain Management to Addiction" International Journal of Molecular Sciences 25, no. 17: 9314. https://doi.org/10.3390/ijms25179314