Obstructive Sleep Apnea and Serotoninergic Signalling Pathway: Pathomechanism and Therapeutic Potential
Abstract
:1. Introduction
2. Materials and Methods
3. Serotonergic Pathway and Its Key Role in Physiology and Pathophysiology of the Human Organism
4. The Role of 5-HT in OSA: Genetics, Pathogenesis, Physiological Functions, and Correlations with Coexisting Pathologies
4.1. Genetics
4.2. Digestion
4.3. Circulation
Genetic Implications | Associations and Manifestations |
---|---|
5-HTTLPR l allele | Associations with OSA severity in older patients; manifested by the increase of AHI by 4.46 per hour of sleep in comparison to alleles [28]. |
5-HT2A receptor polymorphism -1438G/A | Positive risk factor for OSA especially in men [29,30]. |
5-HT2A receptor polymorphism -rs2770304 | Co-occurrence between sleep bruxism and OSA [31]. |
5-HTR2A polymorphism -1438G/A | Greater susceptibility to OSA development [33]. |
5-HT2A rs6313 and rs6311 polymorphisms | Associations between vasoconstriction, hypertension, and atherosclerosis and its relationship with OSA within the Kurdish population [57]. |
5-HT2C receptor knockout in an animal model | Predominant links between weight gain and the pathogenesis of OSA [44]. |
4.4. Sleep
4.5. Respiration
4.6. Muscle Tone and Genioglossal Muscle Activity
5. 5-HT in the Context of OSA and Its Correlation with Psychiatric Comorbidities
5.1. Depression
5.2. Anxiety Disorders
5.3. Cognitive Dysfunction
6. Clinical Implications
6.1. Antidepressants
6.2. Different Medications
6.3. Drugs Combinations
7. Conclusions and Future Directions
Author Contributions
Funding
Conflicts of Interest
References
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Witkowska, A.; Jaromirska, J.; Gabryelska, A.; Sochal, M. Obstructive Sleep Apnea and Serotoninergic Signalling Pathway: Pathomechanism and Therapeutic Potential. Int. J. Mol. Sci. 2024, 25, 9427. https://doi.org/10.3390/ijms25179427
Witkowska A, Jaromirska J, Gabryelska A, Sochal M. Obstructive Sleep Apnea and Serotoninergic Signalling Pathway: Pathomechanism and Therapeutic Potential. International Journal of Molecular Sciences. 2024; 25(17):9427. https://doi.org/10.3390/ijms25179427
Chicago/Turabian StyleWitkowska, Alicja, Julia Jaromirska, Agata Gabryelska, and Marcin Sochal. 2024. "Obstructive Sleep Apnea and Serotoninergic Signalling Pathway: Pathomechanism and Therapeutic Potential" International Journal of Molecular Sciences 25, no. 17: 9427. https://doi.org/10.3390/ijms25179427