Cross-Species Studies Reveal That Dysregulated Mitochondrial Gene Expression and Electron Transport Complex I Activity Are Crucial for Sarcopenia
Abstract
:1. Introduction
2. Results
2.1. Common Pathways across Species Based on Hallmark Gene Set Analysis Using DEGs or Ranked Gene Lists
2.2. The Abnormal Metabolic Process Was Linked to Mitochondrial Respiratory Complexes across Species
2.3. Mitochondrial Complex I Activity along with Mitochondrial Gene Expression Was Significantly Suppressed across Species
2.4. Inflammatory Responses of IFN-γ, TNF-α, and IL-6 Were Central Factors That Induced Abnormal Inflammatory Responses across Species
2.5. Increased and Dysregulated Macrophage Function Was Commonly Detectable across Species
3. Discussion and Conclusions
4. Methods
4.1. Gene Expression Data Acquisition
4.2. Metabolome Data Acquisition
4.3. Pathway Analysis
4.4. Data Visualization
Supplementary Materials
Author Contributions
Funding
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Lee, J.-Y.; Shin, S.-K.; Han, J.-W.; Kwon, E.-Y.; Bae, H.R. Cross-Species Studies Reveal That Dysregulated Mitochondrial Gene Expression and Electron Transport Complex I Activity Are Crucial for Sarcopenia. Int. J. Mol. Sci. 2024, 25, 10302. https://doi.org/10.3390/ijms251910302
Lee J-Y, Shin S-K, Han J-W, Kwon E-Y, Bae HR. Cross-Species Studies Reveal That Dysregulated Mitochondrial Gene Expression and Electron Transport Complex I Activity Are Crucial for Sarcopenia. International Journal of Molecular Sciences. 2024; 25(19):10302. https://doi.org/10.3390/ijms251910302
Chicago/Turabian StyleLee, Ji-Yoon, Su-Kyung Shin, Ji-Won Han, Eun-Young Kwon, and Heekyong R. Bae. 2024. "Cross-Species Studies Reveal That Dysregulated Mitochondrial Gene Expression and Electron Transport Complex I Activity Are Crucial for Sarcopenia" International Journal of Molecular Sciences 25, no. 19: 10302. https://doi.org/10.3390/ijms251910302