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Volume 25
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Investigation of the Pharmacodynamic Components of Gastrodia elata Blume for Treatment of Type 2 Diabetes Mellitus through HPLC, Bioactivity, Network Pharmacology and Molecular Docking

by
Xiu Yang
1,2,3,†,
Lilang Li
1,2,†,
Yanfang Yan
1,2,
Xuehao Hu
1,2,3,
Qiji Li
1,2,
Liangqun Li
1,2,
Yu Wang
1,2,
Xian Tao
1,2,
Lishou Yang
1,2,
Mei Peng
1,2,
Juan Yang
1,2,
Xiaosheng Yang
1,2,* and
Ming Gao
1,2,*
1
State Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China
2
Natural Products Research Center of Guizhou Province, Guiyang 550014, China
3
College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550014, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2024, 25(19), 10498; https://doi.org/10.3390/ijms251910498 (registering DOI)
Submission received: 21 August 2024 / Revised: 25 September 2024 / Accepted: 26 September 2024 / Published: 29 September 2024
(This article belongs to the Section Molecular Pharmacology)
Review Reports Versions Notes

Abstract

The occurrence of type 2 diabetes mellitus (T2DM), a worldwide chronic disease, is mainly caused by insufficient insulin production and places a huge burden on the health system. Gastrodia elata Blume (GE), a food of medicine–food homology, has been reported to have the ability to inhibit glycosidase activity, indicating its potential in the treatment of diabetes. However, the main pharmacological components of GE for the treatment of T2DM have not been fully clarified. Therefore, this study aims to clarify the pharmacological components changes of GE with different drying methods and the treatment of T2DM using HPLC, network pharmacology, molecular docking and experimental evaluations. The results showed that the GE samples processed by the steam-lyophilized method possessed the highest total content of the six marker components and the strongest antioxidant and α-glucosidase inhibitory abilities. Meanwhile, the six marker compounds had a total of 238 T2DM-related gene targets. Notably, these active compounds have good affinity for key gene targets associated with T2DM signaling pathways. In conclusion, this study revealed that different drying methods of GE affect the content of its major active compounds, antioxidant capacity, α-glucosidase inhibitory capacity and potential pharmacological effects on T2DM, indicating that it is a potential treatment of T2DM.
Keywords: Gastrodia elata Blume; type 2 diabetes mellitus (T2DM); α-glucosidase; antioxidant; network pharmacology; molecular docking Gastrodia elata Blume; type 2 diabetes mellitus (T2DM); α-glucosidase; antioxidant; network pharmacology; molecular docking

Share and Cite

MDPI and ACS Style

Yang, X.; Li, L.; Yan, Y.; Hu, X.; Li, Q.; Li, L.; Wang, Y.; Tao, X.; Yang, L.; Peng, M.; et al. Investigation of the Pharmacodynamic Components of Gastrodia elata Blume for Treatment of Type 2 Diabetes Mellitus through HPLC, Bioactivity, Network Pharmacology and Molecular Docking. Int. J. Mol. Sci. 2024, 25, 10498. https://doi.org/10.3390/ijms251910498

AMA Style

Yang X, Li L, Yan Y, Hu X, Li Q, Li L, Wang Y, Tao X, Yang L, Peng M, et al. Investigation of the Pharmacodynamic Components of Gastrodia elata Blume for Treatment of Type 2 Diabetes Mellitus through HPLC, Bioactivity, Network Pharmacology and Molecular Docking. International Journal of Molecular Sciences. 2024; 25(19):10498. https://doi.org/10.3390/ijms251910498

Chicago/Turabian Style

Yang, Xiu, Lilang Li, Yanfang Yan, Xuehao Hu, Qiji Li, Liangqun Li, Yu Wang, Xian Tao, Lishou Yang, Mei Peng, and et al. 2024. "Investigation of the Pharmacodynamic Components of Gastrodia elata Blume for Treatment of Type 2 Diabetes Mellitus through HPLC, Bioactivity, Network Pharmacology and Molecular Docking" International Journal of Molecular Sciences 25, no. 19: 10498. https://doi.org/10.3390/ijms251910498

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