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Article

Serum Vitamin D3 as a Potential Biomarker for Neuronal Damage in Smoldering Multiple Sclerosis

by
Natalia Niedziela
1,*,
Maria Nowak-Kiczmer
1,
Lina Malciene
2,
Mariusz Stasiołek
3,
Jacek T. Niedziela
4,
Zenon P. Czuba
5,
Martyna Lis
1,
Agata Sowa
1 and
Monika Adamczyk-Sowa
1
1
Department of Neurology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, ul. 3-go Maja 13-15, 41-800 Zabrze, Poland
2
Klaipeda University Hospital, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania
3
Department of Neurology, Medical University of Lodz, ul. Kopcińskiego 22, 90-153 Lodz, Poland
4
3rd Department of Cardiology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Silesian Centre for Heart Disease ul, M.C. Sklodowskiej 9, 41-800 Zabrze, Poland
5
Department of Microbiology and Immunology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, ul. Jordana 19, 41-808 Zabrze, Poland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(19), 10502; https://doi.org/10.3390/ijms251910502
Submission received: 8 September 2024 / Revised: 24 September 2024 / Accepted: 27 September 2024 / Published: 29 September 2024
(This article belongs to the Section Molecular Endocrinology and Metabolism)
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Abstract

Permanent inflammatory demyelinating and neurodegenerative processes lead to neurological disability in patients with multiple sclerosis (MS). The anti-inflammatory properties of vitamin D3 (VitD) are well established, but its role in neurodegeneration is still uncertain. The usefulness of the serum concentration of VitD as a potential biomarker in evaluating brain injury in terms of recently known smoldering MS was under consideration. Methods: We assessed the concentrations of the parameters of brain injury (NF-H, GPAF, S100B, UCHL1) in the cerebrospinal fluid (CSF) of relapsing-remitting (RRMS, n = 123) and progressive MS (PMS, n = 88) patients in the group with normal levels of VitD (VitDn) and in the VitD deficiency group (VitDd). The levels of NF-H and UCHL1 were higher in the group of VitDd compared to VitDn. The higher serum levels of VitD were correlated with lower concentrations of GFAP, NF-H and S100B in the CSF of the whole group of MS patients and in women with MS as opposed to the levels of UCHL1. In men, there were noted negative correlations between the levels of serum VitD and GFAP and NF-H in CSF but not between VitD and S100B and UCHL1. The negative correlations were observed between VitD and the selected parameters of brain injury in MS patients, in women as well as in men. The concentrations of serum VitD together with selected parameters of brain injury in CSF seem to be promising biomarkers of neurodegeneration processes in smoldering MS.
Keywords: vitamin D3; GPAF; NF-H; S100B; UCHL1; smoldering multiple sclerosis; neurodegeneration; neuroinflammation vitamin D3; GPAF; NF-H; S100B; UCHL1; smoldering multiple sclerosis; neurodegeneration; neuroinflammation

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MDPI and ACS Style

Niedziela, N.; Nowak-Kiczmer, M.; Malciene, L.; Stasiołek, M.; Niedziela, J.T.; Czuba, Z.P.; Lis, M.; Sowa, A.; Adamczyk-Sowa, M. Serum Vitamin D3 as a Potential Biomarker for Neuronal Damage in Smoldering Multiple Sclerosis. Int. J. Mol. Sci. 2024, 25, 10502. https://doi.org/10.3390/ijms251910502

AMA Style

Niedziela N, Nowak-Kiczmer M, Malciene L, Stasiołek M, Niedziela JT, Czuba ZP, Lis M, Sowa A, Adamczyk-Sowa M. Serum Vitamin D3 as a Potential Biomarker for Neuronal Damage in Smoldering Multiple Sclerosis. International Journal of Molecular Sciences. 2024; 25(19):10502. https://doi.org/10.3390/ijms251910502

Chicago/Turabian Style

Niedziela, Natalia, Maria Nowak-Kiczmer, Lina Malciene, Mariusz Stasiołek, Jacek T. Niedziela, Zenon P. Czuba, Martyna Lis, Agata Sowa, and Monika Adamczyk-Sowa. 2024. "Serum Vitamin D3 as a Potential Biomarker for Neuronal Damage in Smoldering Multiple Sclerosis" International Journal of Molecular Sciences 25, no. 19: 10502. https://doi.org/10.3390/ijms251910502

APA Style

Niedziela, N., Nowak-Kiczmer, M., Malciene, L., Stasiołek, M., Niedziela, J. T., Czuba, Z. P., Lis, M., Sowa, A., & Adamczyk-Sowa, M. (2024). Serum Vitamin D3 as a Potential Biomarker for Neuronal Damage in Smoldering Multiple Sclerosis. International Journal of Molecular Sciences, 25(19), 10502. https://doi.org/10.3390/ijms251910502

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