Review of Novel Surgical, Radiation, and Systemic Therapies and Clinical Trials in Glioblastoma

Valerius, Allison R.; Webb, Lauren M.; Thomsen, Anna; Lehrer, Eric J.; Breen, William G.; Campian, Jian L.; Riviere-Cazaux, Cecile; Burns, Terry C.; Sener, Ugur

doi:10.3390/ijms251910570

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Review of Novel Surgical, Radiation, and Systemic Therapies and Clinical Trials in Glioblastoma

by

Allison R. Valerius

^1,*

,

Lauren M. Webb

¹

,

Anna Thomsen

¹,

Eric J. Lehrer

²,

William G. Breen

²,

Jian L. Campian

³,

Cecile Riviere-Cazaux

⁴,

Terry C. Burns

⁴

and

Ugur Sener

^1,3

¹

Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA

²

Department of Radiation Oncology, Mayo Clinic, Rochester, MN 55905, USA

³

Department of Medical Oncology, Mayo Clinic, Rochester, MN 55905, USA

⁴

Department of Neurosurgery, Mayo Clinic, Rochester, MN 55905, USA

^*

Author to whom correspondence should be addressed.

Int. J. Mol. Sci. 2024, 25(19), 10570; https://doi.org/10.3390/ijms251910570

Submission received: 23 August 2024 / Revised: 25 September 2024 / Accepted: 26 September 2024 / Published: 30 September 2024

(This article belongs to the Special Issue Current Developments in Glioblastoma Research and Therapy)

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Abstract

Glioblastoma (GBM) is the most common malignant primary brain tumor in adults. Despite an established standard of care including surgical resection, radiation therapy, and chemotherapy, GBM unfortunately is associated with a dismal prognosis. Therefore, researchers are extensively evaluating avenues to expand GBM therapy and improve outcomes in patients with GBM. In this review, we provide a broad overview of novel GBM therapies that have recently completed or are actively undergoing study in clinical trials. These therapies expand across medical, surgical, and radiation clinical trials. We additionally review methods for improving clinical trial design in GBM.

Keywords: glioblastoma; high-grade glioma; immunotherapy; targeted molecular therapy; surgical therapy; radiation therapy; review of therapy

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MDPI and ACS Style

Valerius, A.R.; Webb, L.M.; Thomsen, A.; Lehrer, E.J.; Breen, W.G.; Campian, J.L.; Riviere-Cazaux, C.; Burns, T.C.; Sener, U. Review of Novel Surgical, Radiation, and Systemic Therapies and Clinical Trials in Glioblastoma. Int. J. Mol. Sci. 2024, 25, 10570. https://doi.org/10.3390/ijms251910570

AMA Style

Valerius AR, Webb LM, Thomsen A, Lehrer EJ, Breen WG, Campian JL, Riviere-Cazaux C, Burns TC, Sener U. Review of Novel Surgical, Radiation, and Systemic Therapies and Clinical Trials in Glioblastoma. International Journal of Molecular Sciences. 2024; 25(19):10570. https://doi.org/10.3390/ijms251910570

Chicago/Turabian Style

Valerius, Allison R., Lauren M. Webb, Anna Thomsen, Eric J. Lehrer, William G. Breen, Jian L. Campian, Cecile Riviere-Cazaux, Terry C. Burns, and Ugur Sener. 2024. "Review of Novel Surgical, Radiation, and Systemic Therapies and Clinical Trials in Glioblastoma" International Journal of Molecular Sciences 25, no. 19: 10570. https://doi.org/10.3390/ijms251910570

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Review of Novel Surgical, Radiation, and Systemic Therapies and Clinical Trials in Glioblastoma

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