Graph Neural Network Model for Prediction of Non-Small Cell Lung Cancer Lymph Node Metastasis Using Protein–Protein Interaction Network and 18F-FDG PET/CT Radiomics
Abstract
:1. Introduction
2. Results
2.1. Gene and Image Texture Feature Selection
2.2. GNN Model
3. Discussion
4. Materials and Methods
4.1. Data Sources
4.2. Gene Analysis
4.3. Image Feature Extraction and Selection
4.4. Prediction Model
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Metrics | Without Image Data | Image Features with AUC ≥ 0.68 | Whole Image Features | |||||
---|---|---|---|---|---|---|---|---|
PET (6) | CT (4) | PET/CT (10) | PET (55) | CT (55) | PET/CT (110) | |||
73 modules * | Accuracy | 0.4795 | 0.5375 | 0.5473 | 0.6420 | 0.7179 | 0.7429 | 0.8455 |
Precision | 0.2679 | 0.4390 | 0.5448 | 0.7633 | 0.7039 | 0.7000 | 0.8392 | |
Recall | 0.4518 | 0.7750 | 0.6321 | 0.6696 | 0.8268 | 0.9018 | 0.9054 | |
F1 score | 0.3248 | 0.5496 | 0.5219 | 0.6354 | 0.7439 | 0.7820 | 0.8631 | |
AUC | 0.5674 | 0.5744 | 0.6532 | 0.7430 | 0.7728 | 0.7907 | 0.8718 | |
Without gene data | Accuracy | - | 0.5920 | 0.6857 | 0.7607 | 0.8357 | 0.8009 | 0.8286 |
Precision | - | 0.5515 | 0.6627 | 0.7662 | 0.7875 | 0.7565 | 0.8026 | |
Recall | - | 0.7625 | 0.8125 | 0.8000 | 0.9339 | 0.9161 | 0.8893 | |
F1 score | - | 0.6363 | 0.7199 | 0.7630 | 0.8522 | 0.8236 | 0.8812 | |
AUC | - | 0.6549 | 0.7415 | 0.8035 | 0.8530 | 0.8372 | 0.8812 | |
Genes in 4 functions (34) ** | Accuracy | 0.5830 | 0.6509 | 0.6018 | 0.7330 | 0.8143 | 0.7955 | 0.8545 |
Precision | 0.4538 | 0.6037 | 0.5858 | 0.7004 | 0.7928 | 0.7548 | 0.8213 | |
Recall | 0.4036 | 0.6946 | 0.6018 | 0.8107 | 0.8768 | 0.9304 | 0.9143 | |
F1 score | 0.3692 | 0.6377 | 0.5805 | 0.7477 | 0.8267 | 0.8238 | 0.8618 | |
AUC | 0.6333 | 0.6776 | 0.7064 | 0.7709 | 0.8901 | 0.8849 | 0.9026 | |
DEG results (19) *** | Accuracy | 0.5411 | 0.6321 | 0.6429 | 0.6973 | 0.8000 | 0.7768 | 0.8223 |
Precision | 0.5239 | 0.6131 | 0.6146 | 0.6916 | 0.7553 | 0.7343 | 0.8006 | |
Recall | 0.5875 | 0.6464 | 0.7357 | 0.7250 | 0.9179 | 0.9179 | 0.8893 | |
F1 score | 0.4910 | 0.6153 | 0.6421 | 0.6963 | 0.8238 | 0.8098 | 0.8345 | |
AUC | 0.5231 | 0.6879 | 0.7092 | 0.7458 | 0.8585 | 0.8245 | 0.8948 | |
Univariate analysis (12) **** | Accuracy | 0.5036 | 0.6045 | 0.7268 | 0.7580 | 0.8134 | 0.7580 | 0.8420 |
Precision | 0.3998 | 0.6098 | 0.6861 | 0.7443 | 0.7660 | 0.7256 | 0.7893 | |
Recall | 0.5893 | 0.6750 | 0.8625 | 0.7982 | 0.9179 | 0.8464 | 0.9607 | |
F1 score | 0.4627 | 0.5929 | 0.7602 | 0.7668 | 0.8325 | 0.7643 | 0.8610 | |
AUC | 0.4784 | 0.7229 | 0.7627 | 0.7765 | 0.8606 | 0.8397 | 0.8793 |
Characteristics | Non Metastasis (n = 73) | Lymph Node Metastasis (n = 20) |
---|---|---|
Age (%) | ||
<65 | 22 (30) | 3 (15) |
≥65 | 51 (70) | 17 (85) |
Mean age (y) | 68.82 | 69.1 |
Sex, n (%) | ||
Male | 56 (77) | 15 (75) |
Female | 17 (23) | 5 (25) |
Pathological stage, n (%) | ||
T1a | 15 (21) | 1 (5) |
T1b | 15 (21) | 7 (35) |
T2a | 26 (36) | 5 (25) |
T2b | 6 (8) | 3 (15) |
T3 | 7 (10) | 2 (10) |
T4 | 4 (5) | 2 (10) |
Pathological stage (%) | ||
N0 | 73 | |
N1 | 7 (35) | |
N2 | 13 (65) | |
Pathological stage (%) | ||
I | 56 (77) | |
II | 13 (18) | 7 (35) |
III | 4 (5.48) | 12 (60) |
IV | 1 (5) |
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Ju, H.; Kim, K.; Kim, B.I.; Woo, S.-K. Graph Neural Network Model for Prediction of Non-Small Cell Lung Cancer Lymph Node Metastasis Using Protein–Protein Interaction Network and 18F-FDG PET/CT Radiomics. Int. J. Mol. Sci. 2024, 25, 698. https://doi.org/10.3390/ijms25020698
Ju H, Kim K, Kim BI, Woo S-K. Graph Neural Network Model for Prediction of Non-Small Cell Lung Cancer Lymph Node Metastasis Using Protein–Protein Interaction Network and 18F-FDG PET/CT Radiomics. International Journal of Molecular Sciences. 2024; 25(2):698. https://doi.org/10.3390/ijms25020698
Chicago/Turabian StyleJu, Hyemin, Kangsan Kim, Byung Il Kim, and Sang-Keun Woo. 2024. "Graph Neural Network Model for Prediction of Non-Small Cell Lung Cancer Lymph Node Metastasis Using Protein–Protein Interaction Network and 18F-FDG PET/CT Radiomics" International Journal of Molecular Sciences 25, no. 2: 698. https://doi.org/10.3390/ijms25020698