Epigenetic Methylation Changes in Pregnant Women: Bisphenol Exposure and Atopic Dermatitis

Kim, Seung Hwan; Yu, So Yeon; Choo, Jeong Hyeop; Kim, Jihyun; Ahn, Kangmo; Hwang, Seung Yong

doi:10.3390/ijms25031579

Open AccessArticle

Epigenetic Methylation Changes in Pregnant Women: Bisphenol Exposure and Atopic Dermatitis

by

Seung Hwan Kim

^1,†

,

So Yeon Yu

^2,†,

Jeong Hyeop Choo

²,

Jihyun Kim

^3,4,

Kangmo Ahn

^3,4 and

Seung Yong Hwang

^5,6,*

¹

Department of Bio-Nanotechnology, Hanyang University, Ansan 15588, Republic of Korea

²

Department of Molecular & Life Science, Hanyang University, Ansan 15588, Republic of Korea

³

Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea

⁴

Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology, Seoul 06355, Republic of Korea

⁵

Department of Medicinal and Life Sciences, Hanyang University, Ansan 15588, Republic of Korea

⁶

Department of Applied Artificial Intelligence, Hanyang University, Ansan 15588, Republic of Korea

^*

Author to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Int. J. Mol. Sci. 2024, 25(3), 1579; https://doi.org/10.3390/ijms25031579

Submission received: 22 December 2023 / Revised: 19 January 2024 / Accepted: 25 January 2024 / Published: 27 January 2024

(This article belongs to the Special Issue New Insights of DNA Methylation)

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Abstract

Bisphenol is a chemical substance widely used in plastic products and food containers. In this study, we observed a relationship between DNA methylation and atopic dermatitis (AD) in the peripheral blood mononuclear cells (PBMCs) of pregnant women exposed to bisphenol A (BPA) and its alternatives, bisphenol S (BPS) and bisphenol F (BPF). DNA methylation is an epigenetic mechanism that regulates gene expression, which can be altered by environmental factors, and affects the onset and progression of diseases. We found that genes belonging to the JAK-STAT and PI3K-AKT signaling pathways were hypomethylated in the blood of pregnant women exposed to bisphenols. These genes play important roles in skin barrier function and immune responses, and may influence AD. Therefore, we suggest that not only BPA, but also BPS and BPF, which are used as alternatives, can have a negative impact on AD through epigenetic mechanisms.

Keywords: bisphenol A; bisphenol S; bisphenol F; atopic dermatitis; DNA methylation; JAK-STAT signaling pathway; PI3K-AKT signaling pathway

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MDPI and ACS Style

Kim, S.H.; Yu, S.Y.; Choo, J.H.; Kim, J.; Ahn, K.; Hwang, S.Y. Epigenetic Methylation Changes in Pregnant Women: Bisphenol Exposure and Atopic Dermatitis. Int. J. Mol. Sci. 2024, 25, 1579. https://doi.org/10.3390/ijms25031579

AMA Style

Kim SH, Yu SY, Choo JH, Kim J, Ahn K, Hwang SY. Epigenetic Methylation Changes in Pregnant Women: Bisphenol Exposure and Atopic Dermatitis. International Journal of Molecular Sciences. 2024; 25(3):1579. https://doi.org/10.3390/ijms25031579

Chicago/Turabian Style

Kim, Seung Hwan, So Yeon Yu, Jeong Hyeop Choo, Jihyun Kim, Kangmo Ahn, and Seung Yong Hwang. 2024. "Epigenetic Methylation Changes in Pregnant Women: Bisphenol Exposure and Atopic Dermatitis" International Journal of Molecular Sciences 25, no. 3: 1579. https://doi.org/10.3390/ijms25031579

APA Style

Kim, S. H., Yu, S. Y., Choo, J. H., Kim, J., Ahn, K., & Hwang, S. Y. (2024). Epigenetic Methylation Changes in Pregnant Women: Bisphenol Exposure and Atopic Dermatitis. International Journal of Molecular Sciences, 25(3), 1579. https://doi.org/10.3390/ijms25031579

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Epigenetic Methylation Changes in Pregnant Women: Bisphenol Exposure and Atopic Dermatitis

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