Current Perspectives of Mitochondria in Sepsis-Induced Cardiomyopathy
Abstract
:1. Introduction
2. Methodology Literature Search
3. The Role of Mitochondria as a Powerhouse in Heart
4. Pathophysiology of SICM
4.1. Mitochondrial Structural Abnormalities
4.2. Autophagy and Mitophagy in SICM
4.3. Calcium Transport-Induced Membrane Potential in SICM
4.4. Mitochondrial Metabolic Abnormality in SICM
4.5. Pyroptosis in SICM
4.6. Ferroptosis in SICM
5. Potential Therapeutic Interventions: Future Perspective
5.1. Therapeutic Strategies for Mitochondria with Antioxidants
5.2. Therapeutic Strategies for Mitochondrial Metabolism in SICM
5.3. Effects of Noncoding RNA Regulation on Mitochondrial Dysfunction in SICM
5.4. Blockade of β Adrenergic Receptor in Sepsis
5.5. Other Approaches
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
References
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NcRNA | Expression in Sepsis | Experimental Models | Mechanisms of Actions | Roles | Reference |
---|---|---|---|---|---|
LncRNA RMPP | ↓ | LPS treated C57BL/6 mice and cardiac muscle cells (HL-1) | Regulation of miR-1-5p/HSP 70 axis | reduction of MMP and ROS | [95] |
LncRNA H19 | ↓ | H9C2 cell line | Regulation of miR-93-5p/SORBS2 axis | Attenuation of MMP and inflammation | [96] |
LncRNA MIAT | ↑ | LPS treated male BALB/c mice and HL-1 cells | Regulation of miR-330-5p/TRAF6/NF-κB axis | Promotion of inflammation and mitochondrial ROS | [94] |
MiR-210-3p | ↑ | CLP treated male Sprague Dawley rats and H9C2 cells | Regulation of NDUFA4 | Promotion of cardiomyocyte apoptosis and mitochondrial dysfunction | [104] |
MiR-21-3p | ↑ | LPS treated C57BL/6/mice and human plasma | Regulation of SORBS2 | Attenuation of myocardial mitochondrial ultrastructure damage and autophagy | [105] |
LncRNA SOX2OT | ↑ | LPS treated mice and LPS treated H9C2 | Regulation of SOX2 | Promotion of mitochondrial dysfunction with reduction of MMP and increase in ROS | [106] |
LncRNA MALAT1 | ↑ | LPS treated H9C2 and CLP treated rats | Regulation of EZH2/USP22 axis | Attenuation of cardiac injury and Nrf2 expression | [107] |
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Kuroshima, T.; Kawaguchi, S.; Okada, M. Current Perspectives of Mitochondria in Sepsis-Induced Cardiomyopathy. Int. J. Mol. Sci. 2024, 25, 4710. https://doi.org/10.3390/ijms25094710
Kuroshima T, Kawaguchi S, Okada M. Current Perspectives of Mitochondria in Sepsis-Induced Cardiomyopathy. International Journal of Molecular Sciences. 2024; 25(9):4710. https://doi.org/10.3390/ijms25094710
Chicago/Turabian StyleKuroshima, Tatsuki, Satoshi Kawaguchi, and Motoi Okada. 2024. "Current Perspectives of Mitochondria in Sepsis-Induced Cardiomyopathy" International Journal of Molecular Sciences 25, no. 9: 4710. https://doi.org/10.3390/ijms25094710